电子束对藏药八味沉香散的辐照效应  

Effect of electron beam irradiation sterilization on the Tibetan medicine Bawei Chenxiang powder

作　　者：德吉卓嘎 王玮 德吉措姆 田蕾[3] 兰利琼[3] 陈浩[4,5] 孙群 高鹏[4,5] DE Jizhuoga;WANGWei;DE Jicuomu;TIAN Lei;LAN Liqiong;CHEN Hao;SUN Qun;GAO Peng(Tibet Institute for Food and Drug Control,Lhasa 850000,China;NMPA Key Laboratory of Quality Evaluation Research in Traditional Chinese Medicine(Tibetan Medicine),Lhasa 850000,China;Sichuan University,Chengdu 610000,China;Sichuan Institute of Atomic Energy,Chengdu 610101,China;Irradiation Preservation Key Laboratory of Sichuan Province,Chengdu 610101,China)

机构地区：[1]西藏自治区食品药品检验研究院,拉萨850000 [2]国家药品监督管理局中药(藏药)质量控制重点实验室,拉萨850000 [3]四川大学,成都610000 [4]四川省原子能研究院,成都610101 [5]辐照保藏四川省重点实验室,成都610101

出　　处：《辐射研究与辐射工艺学报》2022年第5期63-70,共8页Journal of Radiation Research and Radiation Processing

基　　金：四川省重大科技专项(2019ZDZX0003);四川省区域创新项目(2022YFQ0044);辐照保藏四川省重点实验室开放基金(FZBC2022006);四川省科技创新创业苗子工程(2021JDRC0121)资助。

摘　　要：为研究电子束辐照对藏药八味沉香散灭菌效果和其有效成分的影响,采用电子束(0kGy、5kGy、7 kGy、10 kGy)和^(60)Coγ(7 kGy)辐照三个厂家生产的产品,分别在处理后以及在49℃加速贮藏3个月后检测微生物指标和有效成分的变化。结果表明:经不同剂量处理后,电子束辐照和^(60)Coγ辐照均能显著降低八味沉香散内微生物数量至达标;电子束5 kGy辐照后,样品的微生物总数已降低至《中国药典》的要求限度,且其有效成分没有明显变化,吸收剂量至10 kGy时,对其有效成分含量也基本无影响。因此,电子束辐照可以有效提高八味沉香散的卫生指标,5 kGy为八味沉香散的最佳辐照工艺剂量。To evaluate the sterilization effect of electron beam irradiation on Tibetan medicine Bawei Chenxiang powder and the influence on the active ingredients,medicine samples were irradiated with electron beam at doses of 0 kGy,5 kGy,7 kGy,10 kGy,and ^(60)Coγat 7 kGy.The microbial and active substance costunolide levels were measured within 7 d after irradiation and after accelerated storage at 49℃for 3 months,respectively.The results showed that electron beam and ^(60)Coγirradiation significantly reduced the total number of microorganisms in Bawei Chenxiang powder.Irradiation by electron beams at 5 kGy and 10 kGy reduced the total number of microorganisms in Bawei Chenxiang powder to the maximum requirement suggested by the Chinese Pharmacopoeia without significantly decreasing the amount of active ingredient.In conclusion,electron beam irradiation can effectively improve the microbial index of Bawei Chenxing powder,and 5 kGy is the optimal processing dose for this purpose.

关 键 词：电子束 辐照灭菌 八味沉香散 微生物存活数 有效成分 

分 类 号：TL99[核科学技术—核技术及应用]