CV-A16型手足口病患儿血清TNF-α、内毒素水平与高热惊厥发生的相关性分析  

Correlation analysis of serum TNF-α,endotoxin levels and febrile convulsion in children with CV-A16 hand-foot-mouth disease

作　　者：李亚鹏[1] 李琴[1] 李莉[1] 杨拳 LI Yapeng;LI Qin;LI Li;YANG Quan(Department of Pediatrics,Suining Central Hospital,Suining,Sichuan 629000,China)

机构地区：[1]四川省遂宁市中心医院儿科,四川遂宁629000

出　　处：《国际检验医学杂志》2022年第20期2521-2525,共5页International Journal of Laboratory Medicine

基　　金：四川省卫生健康委员会科研项目(20PJ177)。

摘　　要：目的通过检测柯萨奇病毒A组16(CV-A16)型手足口病患儿血清肿瘤坏死因子-α(TNF-α)、内毒素水平,分析二者与患儿发生高热惊厥的相关性。方法选取2018年12月至2021年10月该院收治的100例CV-A16型手足口病患儿作为研究对象,根据是否发生高热惊厥分为高热惊厥组(39例)和非高热惊厥组(61例);另选取同期在该院健康体检的52例儿童作为对照组。检测所有受试儿童血液中性粒细胞比例、血钾、血钠、血钙、血镁、血清TNF-α、内毒素水平;分析CV-A16型手足口病患儿血清TNF-α水平与内毒素水平的相关性、发生高热惊厥的影响因素及二者对发生高热惊厥的诊断价值。结果对照组、非高热惊厥组、高热惊厥组中性粒细胞比例、血清TNF-α、内毒素水平均依次升高,血钙和血镁水平均依次降低,差异均有统计学意义(P<0.05);CV-A16型手足口病患儿血清TNF-α水平与内毒素水平呈正相关(P<0.05);血清TNF-α、内毒素水平升高是CV-A16型手足口病患儿发生高热惊厥的独立危险因素(P<0.05),而血钙、血镁水平升高是CV-A16型手足口病患儿发生高热惊厥的独立保护因素(P<0.05);血清TNF-α、内毒素单项和二者联合检测诊断CV-A16型手足口病患儿发生高热惊厥的受试者工作特征曲线下面积分别为0.810、0.765、0.930,二者联合检测优于血清TNF-α和内毒素单项检测(P<0.05)。结论CV-A16型手足口病患儿血清TNF-α、内毒素水平与患儿高热惊厥的发生有关,可作为诊断CV-A16型手足口病患儿发生高热惊厥的生物学指标。Objective To analyze the correlation between tumor necrosis factor-α(TNF-α)and endotoxin and febrile convulsion by detecting the levels of the two in children with Coxsackievirus A16(CV-A16)hand-foot-mouth disease.Methods A total of 100 children with CV-A16 hand-foot-mouth disease who were treated in the hospital from December 2018 to October 2021 were selected.According to the occurrence of febrile convulsion,they were divided into high febrile convulsion group(39 cases)and non high febrile convulsion group(61 cases).At the same time,another 52 cases of healthy children in the hospital were selected as the control group.Proportion of blood neutrophils,blood potassium,blood sodium,blood calcium,blood magnesium,serum TNF-α,endotoxin levels were measured in all children.The correlation between serum TNF-αand endotoxin levels in children with CV-A16 hand-foot-mouth disease,the influencing factors of febrile convulsion and their diagnostic value in febrile convulsion were analyzed.Results The proportion of neutrophils,serum TNF-α,endotoxin levels in the control group,non high febrile convulsion group and high febrile convulsion group increased in turn,and the levels of blood calcium and blood magnesium levels decreased in turn,and the differences were statistically significant(P<0.05).There was a positive correlation between serum TNF-αand endotoxin levels in children with CV-A16 hand-foot-mouth disease(P<0.05).Increased serum TNF-αand endotoxin levels were independent risk factors for febrile convulsion in children with CV-A16 hand-foot-mouth disease(P<0.05),while increased serum calcium and magnesium levels were independent protective factors for febrile convulsion in CV-A16 hand-foot-mouth disease children(P<0.05).The area under receiver operating characteristic curve of serum TNF-αand endotoxin alone or in combination for the diagnosis of febrile convulsion in children with CV-A16 hand-foot-mouth disease were 0.810,0.765 and 0.930,respectively,and the combined detection of TNF-αand endotoxin was better t

关 键 词：柯萨奇病毒A组16型 手足口病 肿瘤坏死因子-α 内毒素 高热惊厥 

分 类 号：R725.1[医药卫生—儿科] R446.1[医药卫生—临床医学]