miRNA在脓毒症病原微生物诊断中的研究进展  

Research progress of miRNA in pathogenic microbial diagnosis of sepsis

作　　者：孙文杰 张国安 杨晓晖(综述)[1] 刘英富(审校) SUN Wenjie;ZHANG Guoan;YANG Xiaohui;LIU Yingfu(Cangzhou Medical College,Cangzhou,Hebei 061000,China;Cangzhou Nanobody Technology Innovation Center,Cangzhou,Hebei 061000,China)

机构地区：[1]沧州医学高等专科学校,河北沧州061000 [2]沧州市纳米抗体技术创新中心,河北沧州061000

出　　处：《国际检验医学杂志》2022年第20期2550-2553,共4页International Journal of Laboratory Medicine

基　　金：河北省重点研发计划项目(19272404D)。

摘　　要：脓毒症是由感染引起宿主反应失调致危及生命的疾病,具有发病率高、病死率高、发病机制复杂的特点,其早期诊断一直是医学研究的热点问题。目前,常用的脓毒症实验室指标无法提供病原微生物信息。小分子RNA(miRNA)是生物体生理和病理条件下存在的微小RNA,在不同的致病微生物感染患者中呈差异表达,为脓毒症的早期诊断提供了新方向。该文就miRNA在脓毒症病原微生物诊断中的应用综述如下。Sepsis is a life-threatening disease caused by the dysregulated host response to infection,with high incidence rate,high mortality and complex pathogenesis.Its early diagnosis has always been a hot topic in medical research.Currently,common laboratory markers for the diagnosis of sepsis cannot provide the information of pathogenic microorganisms.MicroRNA(miRNA)is a kind of microRNA existing under physiological and pathological conditions of organism.It is differentially expressed in patients with different pathogenic microorganism infection,which provides a new direction for early diagnosis of sepsis.In this paper,the application of miRNA in pathogenic microbial diagnosis of sepsis was reviewed.

关 键 词：小分子RNA 脓毒症 诊断 生物标志物 微生物 

分 类 号：R446.5[医药卫生—诊断学]