夏科雷登结晶与慢性鼻窦炎的相关研究进展  

Research progress of charcot-leyden crystals and chronic sinusitis

作　　者：李莉[1,2] 杨立新 周宁 LI Li;YANG Lixin;ZHOU Ning(the First Affiliated Hospital of Anhui University of Science and Technology,Huainan,Anhui 232000,China;Graduate School of Bengbu Medical College,Bengbu,Anhui 233000,China)

机构地区：[1]安徽理工大学第一附属医院耳鼻喉科,安徽淮南232000 [2]蚌埠医学院研究生院,安徽蚌埠233000

出　　处：《安徽医药》2022年第11期2157-2160,共4页Anhui Medical and Pharmaceutical Journal

基　　金：安徽理工大学校级资助项目(QN2019128)。

摘　　要：夏科雷登结晶(CLCs)是由半乳糖凝集素-10(gal-10)形成的蛋白质晶体,主要由活化的嗜酸粒细胞、嗜碱粒细胞以及一些T细胞产生,也是人类嗜酸粒细胞中含量最高的蛋白质之一。其广泛存在于哮喘、嗜酸粒细胞增多综合征、变应性鼻炎、慢性鼻窦炎(CRS)等嗜酸性疾病中,是导致疾病的直接原因之一,因而成为嗜酸粒细胞类疾病治疗的靶点。这一发现为慢性鼻窦炎的治疗提供了新的思路。现就夏科雷登结晶的研究进展及对慢性鼻窦炎诊断、治疗的意义作一综述。Charcot-Leyden crystals(CLCs) is a kind of protein crystals formed by galectin-10(Gal-10),which are mainly produced by activated eosinophils,basophils,and T cells.CLCs is one of the most abundant proteins in human eosinophils,and it is widely found in eosinophilic diseases such as asthma,eosinophilic syndrome,allergic rhinitis and chronic sinusitis,and is one of the direct causes of these diseases.Therefore,it has become a target for the treatment of eosinophilic diseases.This finding provides a new idea for the treatment of chronic sinusitis.This paper reviews the research progress of CLCs and its significance in the diagnosis and treatment of chronic sinusitis.

关 键 词：鼻窦炎 夏科雷登结晶 嗜酸粒细胞 

分 类 号：R765.41[医药卫生—耳鼻咽喉科]