4-(二苯氨基)苯甲腈的合成  

Synthesis of 4-Diphenylamino Benzonitrile

作　　者：万晓燕 胡向群 马小云 Wan Xiaoyan;Hu Xiangqun;Ma Xiaoyun(School of Chemistry and Materials Science,Guizhou Education University,Guiyang,Guizhou 550018,China)

机构地区：[1]贵州师范学院化学与材料学院,贵州贵阳550018

出　　处：《山东化工》2022年第18期46-49,共4页Shandong Chemical Industry

基　　金：省级大学生创新训练项目“醛肟脱水制备腈的新途径及脱水机理研究”(S202114223057);贵州师范学院校级大学生科研项目(2021DXS012);贵州省千层次创新型人才项目(黔人领发[2015]3号;贵州省普通高等学校青年科技人才成长项目(黔教合KY字[2021]238);贵州省教育厅特色重点实验室建设项目(黔教合KY字[2018]001)。

摘　　要：介绍一种4-(二苯氨基)苯甲腈的合成方法。以三苯胺为起始原料,通过Vilsmeier-Haack反应制得4-(二苯氨基)苯甲醛,4-(二苯氨基)苯甲醛经肟化反应、醋酸铜催化脱水反应生成4-(二苯氨基)苯甲腈。反应条件相对温和,两步反应的总收率为59.7%。通过熔点测定及核磁共振氢谱检测对产品进行了结构表征。A method for the syntheis of 4-(diphenylamino)benzonitrile from triphenylamine was described in this paper.4-(Diphenylamino)benzaldehyde was prepared from triphenylamine by Vilsmeier-Haack reaction,and then 4-(diphenyleimino)benzaldehyde was converted to 4-(diphenylamino)benzonitrile by oximation reaction and dehydration reaction catalyzed by copper acetate.The reaction conditions are relatively mild,and the total yield of the two-step reaction is 59.7%.The product was characterized by comparing of the melting point and XH NMR with the reported values.

关 键 词：三苯胺 脱水反应 Vilsmeier-Haack反应 乙酸铜 

分 类 号：O625.6[理学—有机化学]