5:2轻断食对肥胖2型糖尿病合并代谢相关脂肪性肝病患者肝脏脂肪含量影响的研究  

Effect of 5:2 fasting diet on liver fat content in obesity patients with type 2 diabetes mellitus and metabolic associated fatty liver disease

作　　者：肖艳新[1] 苑阳阳 吴晓丹 王红素 王君[1] XIAO Yanxin;YUAN Yangyang;WU Xiaodan;WANG Jun(Department of Endocrinology,Baoding NO.1 Central Hospital,Baoding 071000,China)

机构地区：[1]保定市第一中心医院内分泌科,071000 [2]中国人民解放军陆军第82集团军医院放射科

出　　处：《中国糖尿病杂志》2022年第9期662-665,共4页Chinese Journal of Diabetes

摘　　要：目的探讨5:2轻断食对肥胖T2DM合并代谢相关脂肪性肝病(MAFLD)患者肝脏脂肪含量的影响。方法选取2020年2~10月于保定市第一中心医院内分泌科治疗的T2DM合并MAFLD患者41例,予5:2轻断食干预治疗24周。观察治疗后患者体重、WC、血脂、血糖、肝酶、C-RP及肝脏脂肪衰减值(CAP)变化。结果治疗24周后,患者体重、BMI、WC、TC、LDL-C、TG、FPG、2 hPG、HbA_(1)c、胰岛素抵抗指数、谷丙转氨酶(ALT)、谷草转氨酶、CAP降低,HDL-C升高(P<0.05)。Pearson相关分析显示,CAP降低与体重、BMI、ALT降低呈正相关(P<0.05)。多元线性回归分析显示,体重、BMI降低是CAP降低的影响因素。结论5:2轻断食可降低肥胖T2DM合并MAFLD患者肝脏脂肪含量,改善肝功能和糖脂代谢紊乱,减轻IR。肝脏脂肪含量降低与体重降低密切相关。Objective To investigate the effect of the 5:2 fasting diet on the contentof liver fat in obese patients with type 2 diabetes mellitus(T2DM)and metabolic associated fatty liver disease(MAFLD).Methods 41 obese patients complicated with T2DM and MAFLD were recruited from February to October2020.All subjects underwent a 5:2 pattern of fasting diet lifestyle intervention for 24 weeks.Body weight,waist circumference,blood lipids and blood glucose profile,liver enzyme,C-reactive protein(C-RP)and controlled attenuation parameters(CAP)of liver fat were measured before and after intervention.Results After 24 weeks of fasting diet intervention,the levels of body weight,body mass index,waist circumference,total cholesterol,low density lipoprotein cholesterol,triglyceride,fasting blood glucose,2 hours blood glucose,glycosylated hemoglobin,insulin resistance index,alanine aminotransferase(ALT),aspartate aminotransferase and CAP decreased(P<0.05),and high density lipoprotein cholesterol increased(P<0.05).Pearson correlation analysis showed that the decrease of CAP was positively correlated with the decrease of body weight,BMI and ALT(P<0.05).Multiple linear regression analysis showed that weight and BMI were the influencing factors of CAP reduction.Conclusion In obese patients with T2DM and MAFLD,5:2 fasting diet can not only reduce weight,but also reduce liver fat content,improve liver function and glucose and lipid metabolism.

关 键 词：代谢相关脂肪性肝病 糖尿病 2型 肥胖 5:2轻断食 肝脏脂肪含量 

分 类 号：R587.1[医药卫生—内分泌] R575[医药卫生—内科学]