固体分散技术在中药制剂中的应用进展  

Application Progress of Solid Dispersion Technology in Chinese Materia Medica Preparation

作　　者：韩贝贝 孙春萌[1,2] Han Beibei;Sun Chunmeng(School of Pharmacy,China Pharmaceutical University,Nanjing 211198;NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients,Nanjing 210009,China)

机构地区：[1]中国药科大学药学院,江苏南京211198 [2]国家药品监督管理局药物制剂及辅料研究与评价重点实验室,江苏南京210009

出　　处：《广东化工》2022年第20期105-107,123,共4页Guangdong Chemical Industry

摘　　要：固体分散技术是一种将药物分散于载体材料之中以形成固体分散体的现代制剂技术,固体分散技术在中药制剂领域的应用为改善中药有效成分的溶出度和生物利用度提供了可行的方法,为中药制剂的现代化研究提供了新的途径。本文对中药固体分散体的应用优势、制备方法和应用现状进行归纳总结,以期能够为中药固体分散技术的研究提供参考。As a modern preparation technology, solid dispersion technology disperses drug into carrier materials to form solid dispersion. The application of solid dispersion technology in Chinese materia medica preparation provides a feasible method to improve the dissolution and bioavailability, as well as provides a new way for the modernization of Chinese materia medica preparation. This paper reviews the application advantages, preparation methods and application status of solid dispersion in Chinese materia medica preparation, thereby providing references for the research of solid dispersion technology in Chinese materia medica.

关 键 词：固体分散技术 中药制剂 生物利用度 溶出度 固体分散体 

分 类 号：R943[医药卫生—药剂学]