席夫碱铋配合物的开发及应用科研成果转化为创新实验的探索及实践  

Exploration and Practice of Development and Biological Activity Study of Schiff-base Bismuth Complexes Scientific Research Achievement Transformation Innovative Experimental Project

作　　者：李传华[1] 徐佳丽 邝洁 王路宝 蒋建宏[1] 叶丽娟[1] 陶李明[1] Li Chuanhua;Xu Jiali;Kuang Jie;Wang Lubao;Jiang Jianhong;Ye Lijuan;Tao Liming(Hunan Provincial Key Laboratory of Xiangnan Rare-Precious Metals Compounds and Application,School of Chemistry and Environmental Science,Xiangnan University,Chenzhou 423000,China)

机构地区：[1]湘南稀贵金属化合物及其应用湖南省重点实验室,湘南学院化学与环境科学学院,湖南郴州423000

出　　处：《广东化工》2022年第19期28-29,33,共3页Guangdong Chemical Industry

基　　金：湖南省普通高等学校教学改革研究项目(湘教通[2021]298号,课题编号:HNJG-2021-0970);湖南省大学生创新创业训练计划项目(湘教通[2022]174号,课题编号:4287);湘南学院一流专业、一流课程、专业综合改革资助教改项目(湘南学院校发[2020]78号,课题编号:22);郴州市科技计划项目(项目编号:ZDYF201910)。

摘　　要：根据课题组的研究工作“席夫碱铋配合物的开发及应用”,设计了“异烟肼缩2-羟基-5-甲氧基水杨醛席夫碱铋配合物的制备”本科综合创新实验,引入本科实验教学。实验以异烟肼和2-羟基-5-甲氧基水杨醛为原料,首先生成异烟肼缩2-羟基-5-甲氧基水杨醛席夫碱(A),然后再与硝酸铋螯合,制备异烟肼缩2-羟基-5-甲氧基水杨醛席夫碱铋配合物(B),并通过红外光谱、核磁共振谱、质谱对化合物的结构进行表征分析。实验内容体现多学科知识点的交叉融合和综合实验技能的训练,在激发学生的科学探究兴趣,培养锻炼学生的综合能力等方面具有积极的作用,实验安全,反应条件温和易控,现象明显,可用于模块化教学,也可以拆分成多个环节实验,适合不同学时的本科实验教学要求,可以进行教学推广。According to the research work “Development and biological activity study of Schiff-base bismuth complexes”, the undergraduate comprehensive innovation experiment “preparation of bismuth(Ⅲ) complex with Isoniazid-derived Schiff base” was designed. Schiff base {N-(2-hydroxy-5-methoxybenzylidene)isonicotinohydrazide} has been synthesized by reaction of isoniazid and 2-hydroxy-5-methoxy salicylicaldehyde. A new bismuth(Ⅲ) Schiff base complex was prepared by using equivalent molar of Schiff base and Bi(NO)·5HO with the assistance of Mannitol. The complex was structurally characterized by single-crystal X-ray diffraction and spectral techniques(FT-IR, NMR and MS). The experimental design reflects the cross integration of multi-disciplinary knowledge points and the training of comprehensive experimental skills, which helps students broaden their horizons, stimulate their interest in scientific research, cultivate their scientific literacy and cultivate their innovation ability. The experiment is safe, the reaction conditions are mild and easy to control, and the phenomenon is obvious. It can be designed as a multi-link experiment, or divided into several module experiments. It is suitable for different undergraduate experimental teaching requirements, and worthy of promotion.

关 键 词：席夫碱 铋配合物 结构表征 科学研究成果 本科创新实验 

分 类 号：TQ[化学工程]