Effect of acupuncture on cerebral blood flow,serum S100β and ALP in the patients with post-stroke mild cognitive impairment in the convalescence stage  

针刺对脑卒中恢复期轻度认知功能障碍患者脑血流、血清S100β和ALP的影响

作　　者：Roukeyanmu Yusufu Mayila Tuerxun Rena Abudusalamu Wen-Ii SHI 肉克艳木·玉素甫;玛依拉·吐尔逊;热娜·阿不都萨拉木;史文莉(新疆医科大学第一附属医院神经内二/针灸推拿科,乌鲁木齐830054;新疆医科大学第一附属医院神经内科,乌鲁木齐830054)

机构地区：[1]Second Department of Neurology/Department of Acupuncture-Moxibustion and Tuina,First Affiliated Hospital of Xinjiang Medical University,Urumchi 830054,China [2]Neurology Department,First Affiliated Hospital of Xinjiang Medical University,Urumchi 830054,China

出　　处：《World Journal of Acupuncture-Moxibustion》2022年第4期305-309,共5页世界针灸杂志（英文版）

摘　　要：Objective:To explore the clinical therapeutic effect and the impacts of acupuncture on cerebral blood flow and serum S100β and alkaline phosphatase(ALP) in the patients with post-stroke mild cognitive impairment in convalescence stage.Methods:A total of 66 cases were randomized into a control group(33 cases) and an observation group(33 cases).The conventional treatment was applied in the control group.On the base of the treatment of the control group,acupuncture was added at Shéntíng(神庭GV24),Bǎihuì(百会GV20),Dàzhuī(大椎GV14),Mìngmén(命门GV4),Shènshū(肾俞BL23),Shénmén(神门HT7) and Xuánzhōng(悬钟GB39) in the observation group.Before and after treatment,separately,Montreal cognitive assessment(MoCA),mini-mental state examination(MMSE) and modified Barthel index(MBI) were assessed in the patients,peak systolic velocity(PSV) and resistance index(RI) and the levels of serum S100β and ALP were measured.At the end of treatment,the clinical therapeutic effect was evaluated in patients of the both groups.Results:After treatment,the scores of MoCA,MMSE and MBI in the observation group were all higher than those in the control group.PSV in the observation group was higher than the control group,while RI,S100β and ALP were lower than those in the control group,indicating the statistical differences(all P <0.05).The total effective rate was 93.75% in the observation group,higher than 67.74% in the control group,showing statistical difference(P <0.05).Conclusion:Acupuncture achieves the definite therapeutic effect on post-stroke mild cognitive impairment in convalescence stage.This therapy improves the cognitive function,the quality of life and cerebral blood flow in the patients and also down-regulates the levels of serum S100β and ALP.Hence,this acupuncture therapy is worthy of clinical promotion.

关 键 词：ACUPUNCTURE Mild cognitive impairment POST-STROKE Cerebral blood flow S100Β ALP 

分 类 号：R246.6[医药卫生—针灸推拿学]