血清胱抑素C、脑钠肽及白细胞介素-33在急性心肌梗死患者中的表达水平及预后价值  

Expression level and prognostic value of serum cystatin C,brain natriuretic peptide and interleukin-33 in patients with acute myocardial infarction

作　　者：吕新才[1] 卢家忠[1] LÜXin-cai;LU Jia-zhong(Department of Cardiology,Fuyang Second People’s Hospital,Fuyang 236015,Anhui Province,China)

机构地区：[1]阜阳市第二人民医院心血管内科,安徽阜阳236015

出　　处：《中国临床药理学杂志》2022年第18期2124-2127,共4页The Chinese Journal of Clinical Pharmacology

摘　　要：目的分析血清胱抑素C(Cys C)、脑钠肽(BNP)及白细胞介素-33(IL-33)在急性心肌梗死患者中的表达水平及预后价值。方法70例急性心肌梗死患者作为试验组,70例体检健康人员作为对照组。比较2组研究对象的血清Cys C、BNP及IL-33水平。根据原始数据绘制受试者工作特征(ROC)曲线。分析2组研究对象的血清Cys C、BNP及IL-33的敏感度和特异性。观察试验组心血管事件的发生与血清Cys C、BNP以及血清IL-33的关系。分析试验组急性心肌梗死患者发生心脏不良事件的比例。结果试验组和对照组患者血清Cys C分别为(1.39±0.27)和(0.81±0.19)mg·L^(-1),血清BNP分别为(389.31±159.36)和(50.34±19.69)pg·mL^(-1),血清IL-33分别为(468.11±62.79)和(378.59±71.62)ng·L^(-1);血清Cys C敏感性、特异性、约登(Youden)指数分别为95.71%,87.50%,0.83;血清BNP敏感性、特异性、Youden指数分别为95.71%,98.02%,0.94;血清IL-33敏感性、特异性、Youden指数分别85.71%,66.29%,0.72。试验组住院期间急性心肌梗死患者的心脏不良事件发生率为7.15%(5例/70例),明显低于随访期间的35.71%(25例/70例),上述所有数据差异均有统计学意义(均P<0.05)。结论血清Cys C、BNP及IL-33在急性心肌梗死患者中的表达水平及预后对临床治疗心肌梗死疾病有参考意义。Objective To analyze the expression levels and prognostic value of serum Cystatin C(Cys C),brain natriuretic peptide(BNP)and serum interleukin-33(IL-33)in patients with acute myocardial infarction.Methods Seventy patients with acute myocardial infarction were as treatment group,and another 70 healthy people who had physical examination were as control group.The serum Cys C,BNP and IL-33 levels of the two groups of subjects were analyzed and compared.Receiver operating characteristic(ROC)curve were drawed based on the original data.The sensitivity and specificity of serum Cys C,BNP and IL-33 of the two groups were analyzed.The relationship between the occurrence of cardiovascular events and serum Cys C,BNP and serum IL-33 in treatment group were observed.The proportion of adverse cardiac events in patients with acute myocardial infarction in treatment group was analyzed.Results Serum Cys C in treatment group and control group were(1.39±0.27)and(0.81±0.19)mg·L^(-1),and serum BNP were(389.31±159.36)and(50.34±19.69)pg·mL^(-1),respectively;serum IL-33 were(468.11±62.79)and(378.59±71.62)ng·L^(-1),respectively.Serum Cys C sensitivity,specificity and Youden index were 95.71%,87.50%,0.83;serum BNP sensitivity,the specificity and Youden index were 95.71%,98.02%and 0.94,respectively;the sensitivity,specificity and Youden index of serum IL-33 were 85.71%,66.29%and 0.72,respectively.The incidence of cardiac adverse events in patients with acute myocardial infarction during hospitalization in treatment group was 7.15%(5 cases/70 cases),which was significantly lower than35.71%(25 cases/70 cases)during the follow-up period.All the above data differences were statistically significant(all P<0.05).Conclusion The analysis of serum Cys C,BNP and IL-33 expression levels and prognostic value in patients with acute myocardial infarction is of high clinical significance and is worthy of clinical promotion.

关 键 词：血清胱抑素C 脑钠肽 白细胞介素-33 急性心肌梗死 心肌缺血坏死 心绞痛 预后 诊断价值 

分 类 号：R97[医药卫生—药品]