微小RNA及其相关信号通路参与糖尿病肾病的研究现状  

Research status of microRNA and related signaling pathways involved in diabetic nephropathy

作　　者：张文宁 马瑜瑾 姜宏卫[1,2,3,4] 彭慧芳 赵冰 赵倩[1,2] ZHANG Wen-ning;MA Yu-jin;JIANG Hong-wei;PENG Hui-fang;ZHAO Bing;ZHAO Qian(Department of Endocrinology,The First Affiliated Hospital of Henan University of Science and Technology,Clinical School of Henan University of Science and Technology,Luoyang 471003,Henan Province,China;Luoyang Key Laboratory of Endocrinology,The First Affiliated Hospital of Henan University of Science and Technology,Clinical School of Henan University of Science and Technology,Luoyang 471003,Henan Province,China;Luoyang Clinical Medical Research Center of Endocrine and Metabolic Diseases,The First Affiliated Hospital of Henan University of Science and Technology,Clinical School of Henan University of Science and Technology,Luoyang 471003,Henan Province,China;National Center for Standardized Management of Metabolic Disease,The First Affiliated Hospital of Henan University of Science and Technology,Clinical School of Henan University of Science and Technology,Luoyang 471003,Henan Province,China)

机构地区：[1]河南科技大学临床医学院河南科技大学第一附属医院内分泌科,河南洛阳471003 [2]河南科技大学临床医学院河南科技大学第一附属医院洛阳市内分泌遗传代谢重点实验室,河南洛阳471003 [3]河南科技大学临床医学院河南科技大学第一附属医院洛阳市内分泌代谢病临床医学研究中心,河南洛阳471003 [4]河南科技大学临床医学院河南科技大学第一附属医院国家标准化代谢性疾病管理中心,河南洛阳471003

出　　处：《中国临床药理学杂志》2022年第18期2229-2233,共5页The Chinese Journal of Clinical Pharmacology

基　　金：河南省省直机构服务能力提升工程建设基金资助项目(2017);河南省中国科学院科技成果转移化基金资助项目(2018105);洛阳市医疗卫生科技计划基金资助项目(1920017A)。

摘　　要：糖尿病肾病(diabetic nephropathy,DN)已成为终末期肾病的首要致病因素以及慢性肾病的主要致死原因。作为基因表达的调控因子,微小RNA(micro RNA,miRNA)及其相关的信号通路与DN的发病机制密切相关,同时也可作为肾疾病的生物预测标志物。本文从miRNA的产生与生物作用,DN的发病机制,转化生长因子β1/Smads信号通路、磷酸酰基醇3激酶/蛋白激酶B信号通路、核因子-κB信号通路、丝裂原活化蛋白激酶信号通路对DN发生发展的影响,miRNA在泛素-蛋白酶体系统中的作用,以及miRNAs作为DN的生物标志物等内容进行综述,为今后DN的诊断和治疗提供参考。Diabetic nephropathy(DN)has become the leading cause of end-stage renal disease and the main cause of death of chronic kidney disease.As regulatory factors of gene expression,microRNA(miRNA)and its related signal pathways are closely related to the pathogenesis of diabetic nephropathy,which can also be used as biological predictive markers of renal disease.This article reviews the relevant contents(production and biological effects of miRNA,the pathogenesis of DN,transforming growth factor-β1/Smads signaling pathway,phosphoacylol 3 kinase/protein kinase B signaling,nuclear factor-B signaling,mitogen-activated protein kinase signaling on DN development,the role of miRNA in the ubiquitin-proteasome system,and miRNAs as a biomarker of DN)to provide reference for the diagnosis and treatment of diabetic nephropathy in the future.

关 键 词：糖尿病肾病 微小RNA 信号通路 分子标志物 

分 类 号：R97[医药卫生—药品]