miR-146a对慢性骨病骨相关细胞增殖、分化、凋亡调控机制的研究现状  

Research status on the regulatory mechanism of miR-146a on proliferation,differentiation and apoptosis of bone related cells in chronic bone disease

作　　者：石瑶 安方玉 颜春鲁 袁灵青 蒋国凤 吕栋辉 赵延真 王嘉玉 蔡成成[6] SHI Yao;AN Fang-yu;YAN Chun-lu;YUAN Ling-qing;JIANG Guo-feng;LÜDong-hui;ZHAO Yan-zhen;WANG Jia-yu;CAI Cheng-cheng(School of Preclinical Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Teaching Experiment Training Center,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;College of Integrated Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Research Center of Traditional Chinese Medicine of Gansu,Lanzhou,73000,Gansu Province,China;Gansu Provincial Key Laboratory of TCM Prevention and Treatment of Chronic Diseases,Lanzhou 730000,Gansu Province,China;Department of Orthopedics,The Second People’s Hospital of Lanzhou City,Lanzhou 730046,Gansu Province,China)

机构地区：[1]甘肃中医药大学基础医学院,甘肃兰州730000 [2]甘肃中医药大学教学实验实训中心,甘肃兰州730000 [3]甘肃中医药大学中西医结合学院,甘肃兰州730000 [4]甘肃省中医药研究中心,甘肃兰州730000 [5]甘肃省中医药防治慢性疾病重点实验室,甘肃兰州730000 [6]兰州市第二人民医院骨科,甘肃兰州730046

出　　处：《中国临床药理学杂志》2022年第18期2234-2238,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(82060872);甘肃省自然科学基金资助项目(20JR5RA616);甘肃省中医药研究中心开放课题基金资助项目(zyzx-2020-zx28);甘肃省“双一流”科研重点基金资助项目(GSSYLXM-05)。

摘　　要：在人体骨骼中,间充质干细胞、成骨细胞、破骨细胞和软骨细胞等细胞共同参与骨代谢,调控异常会导致骨质疏松症、骨关节炎等慢性骨病。研究发现,微小RNA可以调控间充质干细胞、成骨细胞、破骨细胞和软骨细胞等细胞的增殖、分化和凋亡等多种生理病理过程,是调控骨质疏松症、骨关节炎等慢性骨病骨代谢的关键因子。本文着重综述并探讨了微小RNA 146a对间充质干细胞、成骨细胞、破骨细胞和软骨细胞的调控机制,以期为骨质疏松症、骨关节炎等慢性骨病的防治药物的研发与应用提供参考。In human bone,mesenchymal stem cells,osteoblasts,osteoclasts and chondrocytes participate in bone metabolism.Abnormal regulation will lead to chronic bone diseases such as osteoporosis and osteoarthritis.It is found that microRNA can regulate a variety of physiological and pathological processes such as proliferation,differentiation and apoptosis of mesenchymal stem cells,osteoblasts,osteoclasts and chondrocytes.It is a key factor in regulating bone metabolism in chronic bone diseases such as osteoporosis and osteoarthritis.This paper focuses on the regulatory mechanism of microRNA 146 a on mesenchymal stem cells,osteoblasts,osteoclasts and chondrocytes,in order to provide reference for the development and application of drugs for the prevention and treatment of chronic bone diseases such as osteoporosis and osteoarthritis.

关 键 词：微小RNA 146a 间充质干细胞 成骨细胞 破骨细胞 软骨细胞 

分 类 号：R68[医药卫生—骨科学]