冠状动脉瘤样扩张患者血清Adropin蛋白、hs-CRP水平变化及相关性分析  

Correlation analysis of Adropin protein and hs-CRP levels in patients with coronary artery ectasia

作　　者：王丽娜 马娜 刘燕 孙小刚 Wang Lina;Ma Na;Liu Yan;Sun Xiaogang(Department of Cardiology,the Second Hospital of Gansu Province,Lanzhou 730000,China)

机构地区：[1]甘肃省第二人民医院心内科,兰州730000

出　　处：《疑难病杂志》2022年第10期1014-1018,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：甘肃省卫生健康行业科研计划立项项目(SWSKY2020-47)。

摘　　要：目的 探究血清Adropin蛋白、高敏C反应蛋白(hs-CRP)在冠状动脉瘤样扩张患者中的变化及其相关性分析。方法 选取2019年4月—2021年10月因心绞痛就诊于甘肃省第二人民医院心内科并行冠状动脉造影(CAG)检查者340例为研究对象,根据CAG检查结果,以冠状动脉无异常者为对照组73例(NCA组),单纯冠状动脉瘤样扩张(CAE)组98例(A组),CAE合并阻塞性冠状动脉疾病(OCAD)组52例(B组),OCAD组117例(C组)。收集所有受试者临床资料、血清炎性指标及生化指标水平,比较各组间血清Adropin和hs-CRP水平的差异,使用Pearson法分析CAE患者血清Adropin与hs-CRP的相关性,使用Logistic回归分析判断CAE发生的影响因素。结果 A、B、C组患者吸烟史、糖尿病占比,IL-6、TNF-α水平均高于NCA组(F/P=7.845/0.047、8.311/0.040、64.304/<0.001、56.600/<0.001);血清Adropin水平比较,A组<B组<C组<NCA组,hs-CRP水平比较,A组>B组>C组>NCA组(F/P=217.14/<0.001、572.302/<0.001);CAE患者血清Adropin与hs-CRP呈负相关(r=-0.522,P<0.001)。Logistic回归分析显示,有吸烟史、糖尿病及血清IL-6、TNF-α、hs-CRP水平升高为CAE发生的独立危险因素[OR(95%CI)=4.676(2.619~8.348)、1.917(1.634~2.253)、1.634(1.428~1.869)、1.523(1.306~1.775)、1.839(1.584~2.136)],血清Adropin水平升高为CAE发生的独立保护因素[OR(95%CI)=0.790(0.735~0.849)]。结论 CAE患者血清Adropin呈低表达、hs-CRP呈高表达,且Adropin与hs-CRP呈负相关,二者均是CAE的独立影响因素。Objective To explore the changes and correlation analysis of serum Adropin protein and high-sensitivity C-reactive protein(hs-CRP) in patients with coronary aneurysm ectasia(CAE).Methods Three hundred and forty patients with coronary angiography(CAG) who were hospitalized in the Department of Cardiology of the Second People’s Hospital of Gansu Province from April 2019 to October 2021 due to angina pectoris were selected as the study objects.According to the results of CAG,73 patients without coronary artery abnormalities were selected as the control group(NCA group),98 patients in the simple coronary aneurysm ectasia(CAE) group(group A),52 patients in the CAE combined with obstructive coronary artery disease(OCAD) group(group B),and 117 patients in the OCAD group(group C).Collect the clinical data,serum inflammatory index and biochemical index level of all subjects,compare the difference of serum Adropin and hs-CRP levels among groups,analyze the correlation between serum Adropin and hs-CRP in patients with CAE using Pearson method,and determine the influencing factors of CAE using logistic regression analysis.Results Smoking history,proportion of diabetes mellitus,IL-6,TNF-α level in group A,B and C was higher than that of NCA group(F/P=7.845/0.047,8.311/0.040,64.304/ Group B > Group C > NCA(F/P=217.14/<0.001,572.302/<0.001);Serum Adropin in CAE patients was negatively correlated with hs-CRP(r=-0.522,P<0.001).Logistic regression analysis showed that smoking history,diabetes and the increase of serum IL-6,TNF-α、 hs-CRP level was an independent risk factor for CAE [OR(95% CI)=4.676(2.619-8.348),1.917(1.634-2.253),1.634(1.428-1.869),1.523(1.306-1.775),1.839(1.584-2.136)],and the increase of serum Adropin level was an independent protective factor for CAE [OR(95%CI)=0.790(0.735-0.849)].Conclusion Serum Adropin was low expression and hs-CRP was high expression in patients with CAE,and Adropin was negatively correlated with hs-CRP,both of which were independent risk factors for CAE.

关 键 词：冠状动脉瘤样扩张 Adropin蛋白 高敏C反应蛋白 冠状动脉造影 相关性 

分 类 号：R541.9[医药卫生—心血管疾病]