雌激素受体β基因多态性与男性不育相关性meta分析  

Meta-analysis of the correlation between estrogen receptorβgene polymorphism and male infertility

作　　者：周青 刘帅妹 张瑞金 李孟兰 林宁 封婕 黄丽丽 吴玉璘 ZHOU Qing;LIU Shuaimei;ZHANG Ruijin;LI Menglan;LIN Ning;FENG Jie;Huang Lili;WU Yulin(Jiangsu Health Development Research Center,National Health and Family Planning Commission Contraceptives Adverse Reaction Surveillance Center,Nanjing,Jiangsu Province,210036)

机构地区：[1]江苏省卫生健康发展研究中心国家卫健委重点实验室计划生育药具不良反应监测中心,南京210036

出　　处：《中国计划生育学杂志》2022年第10期2181-2188,共8页Chinese Journal of Family Planning

基　　金：江苏省计划生育科学技术研究所科研启动基金(JSFP2018003)。

摘　　要：目的:评价雌激素受体β基因rs1256049和rs4986938位点多态性与男性不育之间的关系.方法:检索中国知网、pubmed、万方等中英文数据库中相关文献,采用State软件对纳入文献进行meta分析.结果:关于rs1256049位点11篇文献共纳入男性不育患者1914例,健康男性2012例;关于rs4986938位点10篇文献共纳入男性不育患者2136例,健康男性2257例;ERβ(rs1256049)基因AG比GG(OR=1.35,95%CI1.01~1.80)提示ERβ(rs1256049)基因多态性可能与男性不育存在相关性.根据不同人种和基因分型方法进行亚组分析发现,3种比较模型A比G(OR=2.47,95%CI1.37~4.44)、AG比GG(OR=2.51,95%CI1.34~4.72)和AA+AG比GG(OR=2.55,95%CI1.38~4.73)提示ERβ基因rs1256049位点多态性可能会增加高加索男性不育的风险;ERβ(rs4986938)基因5种模型均无统计学意义,根据基因分型方法进行亚组分析,AG比GG(OR=0.48,95%CI0.24~0.94)提示男性不育风险降低.结论:ERβ基因rs1256049位点可能是男性不育易感位点,而rs4986938位点AG基因型可能会降低男性不育风险.Objective: To evaluate the correlation between gene polymorphisms in rs1256049 and rs4986938 sites of estrogen receptor β(ERβ) and male infertility. Methods: The related literatures were retrieved from CNKI, Pubmed, Wanfang, and so on. State software was used for statistical analysis. Results: This meta-analysis included 11 articles on rs1256049 site of 1914 infertility and 2012 healthy males, and 10 articles on rs4986938 SNP site of 2136 infertility and 2257 healthy males. For the rs1256049 site of ERβ, there was significant correlation between gene AG and gene GG(OR=1.35, 95%CI: 1.01-1.80), which suggested that gene polymorphisms in rs1256049 site of ERβof males was correlation with their infertility. The subgroup analysis based on different race and genotyping methods showed that the models of A compared with G(OR=2.47, 95%CI:1.37-4.44), AG compared with GG(OR=2.51, 95%CI 1.34-4.72), and AA + AG compared with GG(OR=2.55, 95%CI 1.38-4.73) suggested that gene polymorphisms in rs4986938 site of ERβof males increased risks the infertility of Caucasian males. There were no significant different among 5 comparison models of gene in rs4986938 site of ERβ. In the subgroup analysis according to the genotyping methods, the gene AG compared with GG(OR=0.48, 95%CI 0.24-0.94) suggested that decreased risk of male infertility. Conclusion: Gene rs1256049 site of ERβmay be a susceptible site of male infertility, while AG genotype of rs4986938 site of ERβ may reduce the risk of male infertility.

关 键 词：雌激素受体β基因 男性不育 META分析 

分 类 号：R698.2[医药卫生—泌尿科学]