妊娠期抑郁危险因素分析及相关妊娠结局观察研究  

Observational study on the risk factors of the depression and the pregnancy outcomes of women during pregnancy

作　　者：龚明霞 黄郁馨 杜丹 潘东娜 潘石蕾 GONG Mingxia;HUANG Yuxin;DU Dan;PAN Dongna;PAN Shilei(The Second School of Clinical Medicine,Southern Medical University,Guangzhou,Guangdong Province,510280;Zhuhai District Maternal and Child Health Care Hospital of Guangzhou)

机构地区：[1]南方医科大学第二临床医学院,广州510280 [2]广东省广州市海珠区妇幼保健院

出　　处：《中国计划生育学杂志》2022年第10期2194-2199,共6页Chinese Journal of Family Planning

摘　　要：目的:调查妊娠期抑郁发生状况,分析影响因素以及对妊娠结局的可能影响.方法:便利抽样法选取2022年3月1日-2022年6月30日在广州市海珠区妇幼保健院产前检查的孕妇462例,根据抑郁量表(EPDS)评估妊娠期抑郁情况并分为抑郁组及非抑郁组.问卷收集孕妇基本资料,分析筛选可能危险因素,检测孕妇糖脂代谢指标及随访不良妊娠结局并分析与妊娠期抑郁的关系.结果:462例孕妇EPDS评分8.03±4.20分,其中抑郁组155例(33.6%)(中重度抑郁59例、轻度抑郁96例),非抑郁组307例(66.5%).单因素分析显示,抑郁组与非抑郁组孕前体质指数、饮食结构、意外妊娠、不孕史、孕期运动锻炼、与配偶的关系、睡眠状况存在差异(P<0.05);logistic多因素回归分析显示,不孕史并非妊娠期抑郁的独立危险因素(P<0.05),孕前体质指数高、饮食结构不平衡、意外妊娠、孕期不经常锻炼、与配偶的关系不和谐、睡眠状况不满意均为妊娠期抑郁的独立危险因素(P<0.05);孕期抑郁与孕晚期空腹血糖、胆固醇、三酰甘油水平均未见相关性(均P>0.05);随访妊娠结局,抑郁组剖宫产(42.0%)、新生儿低血糖比例(8.0%)均高于非抑郁组(24.5%、0)(均P<0.05).结论:妊娠期抑郁不利于妊娠结局,提示临床产科可参考危险因素进行关注,必要时进行针对性干预,降低不良妊娠结局发生.Objective: To investigate the depression status of women during pregnancy, and to analyze the influencing factors of the depression of these women and the influence on their pregnancy outcomes. Methods: The convenience sampling method was used to select 462 pregnant women who underwent obstetric examination and were divided into group A(women with depression) and group B(women without depression) according to Edinburgh Postnatal Depression Scale(EPDS) from March 1, 2022 to June 30, 2022. The questionnaire was used to collect the basic information of these women, and the possible risk factors of depression of the women were analyzed and screened. The levels of glucose and lipid metabolism indicators of the women were detected, and the adverse pregnancy outcomes of the women were followed up. The correlation between the depression of the women and their adverse pregnancy outcomes was analyzed. Results: The EPDS score of 462 pregnant women was 8.03±4.20 points. There were 155(33.6%) women in group A(59 cases with moderate to severe depression and 96 cases with mild depression), and there were 307(66.5%) women in group B. Univariate analysis showed that there were significant differences in the pre-pregnancy body mass index value, the diet structure, and the rates of unintended pregnancy, history of infertility, less exercise during pregnancy, disharmony relationship with their spouse, and unsatisfied sleep status of the women between group A and group B(P<0.05). Logistic multifactor regression analysis shows that the history of infertility was not the independent risk factor of depression of the women during pregnancy(P>0.05), but the high pregnancy body mass index value, the unbalanced diet, the unintended pregnancy, the less exercise during pregnancy, the disharmony relationship with their spouse, the unsatisfied sleep condition were the independent risk factors of depression of the women during pregnancy(P<0.05).The levels of fasting blood glucose,cholesterol,and triacylglycerol(TG)of the women during the third

关 键 词：妊娠期抑郁 不良妊娠结局 糖脂代谢 影响因素 

分 类 号：R714[医药卫生—妇产科学]