滋肾安胎汤联合HCG、黄体酮治疗先兆流产疗效及对患者内分泌及免疫指标的影响  

Effect of Zishen antai decoction combined with chorionic gonadotropin and progesterone for treating women with threatened abortion and its influence on their endocrine and immune indexes

作　　者：邓丽丽 邱翠华[1] 孟玉会 陈静[1] DENG Lili;QIU Cuihua;MENG Yuhui;CHEN Jing(Bengbu Hospital of Traditional Chinese Medicine(Bengbu Sixth People's Hospital),Anhui Province,233000)

机构地区：[1]安徽省蚌埠市中医医院(蚌埠市第六人民医院),233000

出　　处：《中国计划生育学杂志》2022年第10期2208-2212,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨滋肾安胎汤联合绒毛膜促性腺激素(HCG)、黄体酮治疗先兆流产临床效果.方法:选择2018年7月-2020年10月在本院诊治的先兆流产患者104例,随机抽签法分西医组52例和中西医组52例,两组均采用HCG联合黄体酮治疗,中西医组加用滋肾安胎汤,均治疗2周评估临床疗效,分析用药前及用药2周后两组患者中医症候积分[小腹坠痛、阴道出血、腰酸痛、两膝酸软]、内分泌激素[β-人绒毛膜促性腺激素(β-hCG)、孕酮(P)、雌二醇(E_(2))]、Th1/Th2细胞因子[γ干扰素(IFN-γ)、白细胞介素2(IL-2)、白细胞介素4(IL-4)]及免疫指标[T淋巴细胞亚群(CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+))]改变.结果:用药2周后,治疗总有效率中西医组(94.2%)高于西医组(80.8%),两组小腹坠痛、阴道出血、腰酸痛、两膝酸软症候积分均降低且中西医组低于西医组;两组β-hCG、P、E_(2)指标均升高且中西医组高于西医组,两组INF-γ、IL-2指标均降低,IL-4指标升高且中西医组变化幅度高于西医组,两组CD4^(+)、CD8^(+)升高,CD4^(+)/CD8^(+)降低且中西医组变化幅度高于西医组(均P<0.05).结论:滋肾安胎汤联合HCG、黄体酮治疗先兆流产能更好地减轻患者临床症状、提高性激素水平、改善免疫功能,提高临床疗效.Objective: To explore the clinical effect of Zishen antai decoction combined with chorionic gonadotropin(HCG)and progesterone for treating women with threatened abortion.Methods:104 women with threatened abortion who wanted diagnosis and treatment were selected and were divided into two groups according to random lottery from July 2018 to October 2020.52 women in the control group were treated with HCG combined with progesterone for 2 weeks,and 52 women in the observation group were treated with Zishen antai decoction combined with HCG and progesterone for 2 weeks.The clinical efficacy of the women in the two groups was evaluated.The TCM syndrome scores,such as lower abdominal pain,the vaginal bleeding volume,the backache rate,and the knees sore,of the women before and in 2 weeks after treatment,the levels of endocrine hormone,such asβ-human chorionic gonadotropin(β-hCG),Progesterone(P),and estradiol(E_(2)),the levels of Th1/Th2 cytokines,such asγinterferon(IFN-γ),interleukin 2(IL-2),and interleukin 4(IL-4),and the value changes of immune indicators,such as T lymphocyte subsets(CD4^(+),CD8^(+)and CD4^(+)/CD8^(+))of the women in the two groups were analyzed.Results:After 2 weeks of treatment,the total effective rate(94.2%)of the women in the observation group was significantly higher than that(80.8%)of the women in the control group.The score of lower abdominal pain,the vaginal bleeding volume,the backache rate,and the knees sore rate of the women in the observation group were significantly lower than those of the women in the control group(P<0.05).The levels ofβ-hCG,P,and E_(2) of the women in the two groups had increased significantly,and which of the women in the observation group were significantly higher than those of the women in the control group.The levels of INF-γand IL-2 of the women in the two groups had decreased significantly,and the level of IL-4 had increased significantly,and the changes of which of the women in the observation group were significantly more than those of the women in the in c

关 键 词：先兆流产 滋肾安胎汤 绒毛膜促性腺激素 黄体酮 性激素 免疫功能 临床疗效 

分 类 号：R714.21[医药卫生—妇产科学]