妊娠期糖尿病孕妇小肠细菌过度生长情况及其不良妊娠结局  

The situation of small intestine bacterial overgrowth and the adverse pregnancy outcomes of women with gestational diabetes mellitus

作　　者：董延华[1] 韩宁[1] 许雅娟[1] DONG Yanhua;HAN Ning;XU Yajuan(The Third Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan Province,450052)

机构地区：[1]郑州大学第三附属医院,450052

出　　处：《中国计划生育学杂志》2022年第10期2362-2364,共3页Chinese Journal of Family Planning

摘　　要：目的:探讨妊娠期糖尿病发生小肠细菌过度生长(SIBO)情况及其不良妊娠结局.方法:选取2018年1月-2019年1月在本院妇产科接受治疗的GDM患者98例为观察组,产前检查健康孕妇49例为对照组.均给予甲烷-氢呼气试验检测两组孕妇小肠细菌过度生长(SIBO)情况,比较观察组妊娠结局.结果:观察组中SIBO发生率(34.7%,34例)高于对照组(14.3%,7例),羊水过多(9.2%)、早产(10.2%)、胎儿窘迫(14.3%)发生率均高于对照组(2.0%、4.1%、6.1%)(均P<0.05);观察组中SIBO阳性孕产妇发生早产(20.6%)、羊水过多(17.7%)、胎儿窘迫(26.5%)几率均高于阴性孕产妇(4.7%、4.7%、7.8%)(均P<0.05).结论:SIBO发生可能与GDM孕妇发生不良妊娠结局有关,临床可利用甲烷-氢呼气试验检测孕妇SIBO,并对阳性者给予积极治疗.Objective: To investigate the situation of small intestine bacterial overgrowth(SIBO) and the adverse pregnancy outcomes of pregnant women with gestational diabetes mellitus(GDM). Methods: 98 pregnant women with GDM were randomly selected in observation group, and 49 healthy pregnant women were selected in control group from January 2018 to January 2019. The women in both groups were given hydrogen/methane breath test to observe the situation of SIBO. The pregnancy outcomes of the women were compared between the two groups. Results: The incidence of SIBO(34 cases, 34.7%) of the women in the observation group was significantly higher than those(7 cases, 14.3%) of the women in the control group. The incidences of hydramnios(9.2%), preterm birth(10.2%), and fetal distress(14.3%) of the women in the observation group were significantly higher than those(2.0%, 4.1%, and 6.1%) of the women in the control group(all P<0.05). In the observation group, the rates of premature birth(20.6%), polyhydramnios(17.7%), and fetal distress(26.5%) of the women with positive SIBO were significantly higher than those(4.7%, 4.7%, and 7.8%) of the women with negative SIBO(all P<0.05). Conclusion: SIBO may be associated with GDM of the pregnant women, hydrogen/methane breath test can be used for detecting SIBO of the women, and the women with positive SIBO should be treated actively.

关 键 词：妊娠期糖尿病 甲烷-氢呼气试验 小肠细菌过度生长 不良妊娠结局 

分 类 号：R714.256[医药卫生—妇产科学]