基于微针的经皮免疫的应用现状及研究进展  

Microneedle-based percutaneous immunity:a review

作　　者：李月 王菁 金志颖 万伟[1] 白雪欣 胡宸艺 李岩伟 辛文文 康琳 杨浩 王景林 高姗 LI Yue;WANG Jing;JIN Zhiying;WAN Wei;BAI Xuexin;HU Chenyi;LI Yanwei;XIN Wenwen;KANG Lin;YANG Hao;WANG Jinglin;GAO Shan(Institute of Microbiology and Epidemiology,Academy of Military Medical Sciences,Beijing 100071,China)

机构地区：[1]军事科学院军事医学研究院微生物流行病研究所,北京100071

出　　处：《生物工程学报》2022年第9期3301-3315,共15页Chinese Journal of Biotechnology

基　　金：北京市科技新星计划(Z201100006820028)。

摘　　要：微针经皮免疫借助微针刺破皮肤的角质层,使疫苗高效地被抗原提呈细胞识别后引起特异性免疫应答,从而实现疫苗的经皮免疫。由于微针的经皮免疫所具有的高效诱导免疫应答、低痛感、易储存等优点,近年来被广泛应用于多种疫苗免疫接种。本综述对用于经皮免疫的各类微针(固体微针、空心微针、涂层微针和可溶性微针)的制备材料、在经皮免疫的应用、领域的研究热点与尚需要解决的问题进行探讨,以期为研究者的制备和应用提供参考和借鉴。Microneedle percutaneous immunization is achieved by puncturing the stratum corneum of the skin with microneedles so that the vaccine is efficiently recognized by antigen-presenting cells to induce a specific immune response.Due to the advantages of efficient induction of immune response,low pain and easy storage,transdermal immunization by microneedles has been widely used for immunization of various vaccines in recent years.This review summarizes the materials of microneedles,application for transcutaneous immunization,as well as the challenges that need to be addressed.

关 键 词：微针 疫苗 经皮免疫 CITESPACE 

分 类 号：R392-33[医药卫生—免疫学]