Functionalized nanographene oxide/PEG/rhodamine B/gold nanocomposite for electrochemical determination of glucose  

作　　者：Wenhao Qian Tao Song Mao Ye Xiaoyu Huang Yongjun Li Bingjie Hao 

机构地区：[1]Department of Stomatology Shanghai Xuhui District Dental Center,500 Fenglin Road,Shanghai 200032,China [2]Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules,Center for Excellence in Molecular Synthesis,Chinese Academy of Sciences,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Journal of Materials Science & Technology》2022年第27期141-147,共7页材料科学技术（英文版）

基　　金：the financial support from National Science Fund for Distinguished Young Scholars(No.51825304);National Natural Science Foundation of China(No.52103094);Science and Technology Commission of Shanghai Municipality(Nos.20ZR1452200 and 22S31902900);Program for Outstanding Medical Academic Leader(No.2019LJ27);Shanghai Medical Key Specialty(No.ZK2019B12)。

摘　　要：Diabetes,one of the most serious metabolism diseases,has continually plagued human beings so that timely monitored blood glucose level is very necessary.Gold nanoparticles(Au NPs)have been considered as potential substitutes for non-enzymatic sensors,due to their unusual physicochemical property and efficient catalytic activity.Herein,we prepared a facial platform for Au NPs to maintain good dispersity and inherent physicochemical property.In this special platform(SH-n GO-PEG-Rh B),nanographene oxide(n GO)was employed as an ideal base,which provided adequate carboxyls for conjugating with poly(ethylene glycol)(PEG),and enough epoxy groups for thiol active site.A functional dye(rhodamine B)with preferable fluorescence properties was also introduced into this platform.Au NPs were then aptly in situ grown on the platform via reduction of HAuCl_(4) under mild conditions,providing Au NPs@SHn GO-PEG-Rh B.The nanocomposite was cast on a glassy carbon electrode(GCE)conveniently,yielding GCE/Au NPs@SH-n GO-PEG-Rh B.Reasonably,as shown by cyclic voltammetry(CV)and ready-state amperometry,GCE/Au NPs@SH-n GO-PEG-Rh B was capable of electrochemical determination of glucose so as to provide an efficient sensor for glucose determination with dye tracer.

关 键 词：Nano-graphene oxide Gold nanoparticles GLUCOSE BIOSENSOR Rhodamine B 

分 类 号：O657.1[理学—分析化学] R313[理学—化学]