Bioinspired Rotation Microneedles for Accurate Transdermal Positioning and Ultraminimal-Invasive Biomarker Detection with Mechanical Robustness  

作　　者：Yilin Cai Shiyi Huang Zhinan Zhang Jiazheng Zhang Xingyue Zhu Xiaoxiang Chen Xianting Ding 

机构地区：[1]State Key Laboratory of Mechanical System and Vibration,School of Mechanical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China [2]State Key Laboratory of Oncogenes and Related Genes,Institute for Personalized Medicine,School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200030,China [3]Department of Rheumatology,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China

出　　处：《Research》2022年第3期45-59,共15页研究（英文）

基　　金：the State Key Laboratory of Mechanical System and Vibration(Grant No.MSVZD202108);Base for Interdisciplinary Innovative Talent Training.The authors thank all who provided direct technical help and indirect assistance for the study。

摘　　要：Microneedle permits transdermal biosensing and drug delivery with minor pain.However,accurate microneedle transdermal positioning with minimal skin deformation remains a significant technical challenge due to inhomogeneous skin topology and discontinuous force applied to the microneedle.Here,we introduce bioinspired rotation microneedles for in vivo accurate microneedle positioning as inspired by honeybees’stingers.We demonstrate the benefits of rotation microneedles in alleviating skin resistance through finite element analysis,full-thickness porcine validations,and mathematical derivations of microneedleskin interaction stress fields.The max penetration force was mitigated by up to 45.7%and the force attenuation rate increased to 2.73 times in the holding stage after penetration.A decrease in max skin deflection and a faster deformation recovery introduced by rotation microneedles implied a more precise penetration depth.Furthermore,we applied the rotation microneedles in psoriasis mice,a monogenic disorder animal model,for minimally invasive biological sample extraction and proinflammatory cytokine monitoring.An ultrasensitive detection method is realized by using only one microneedle to achieve cytokine mRNA level determination compared to commonly required biopsies or blood collection.Thus,rotation microneedles permit a simple,rapid,and ultraminimal-invasive method for subcutaneous trace biological sample acquisition and subsequent point-of-care diagnostics with minimal damage to both microneedles and skins.

关 键 词：ROTATION precise faster 

分 类 号：TH77[机械工程—仪器科学与技术]