Bionic Microbubble Neutrophil Composite for InflammationResponsive Atherosclerotic Vulnerable Plaque Pluripotent Intervention  

作　　者：Fangfang Liu Yang Mao Jiaqi Yan Yu Sun Zhihua Xie Fei Li Fei Yan Hongbo Zhang Pengfei Zhang 

机构地区：[1]The Key Laboratory of Cardiovascular Remodeling and Function Research,Chinese Ministry of Education,Chinese National Health Commission and Chinese Academy of Medical Sciences,The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine,Department of Cardiology,Qilu Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250012,China [2]Turku Bioscience Centre,University of Turku andÅbo Akademi University,And Pharmaceutical Sciences Laboratory,Åbo Akademi University,Turku 20520,Finland [3]Department of Ultrasound in Medicine,The Second Affiliated Hospital of Zhejiang University School of Medicine,No.88 Jiefang Road,Shangcheng District,Hangzhou 310009,China [4]Shenzhen Institute of Advanced Technology,Chinese Academy of Science,Shenzhen 518055,China

出　　处：《Research》2022年第3期105-115,共11页研究（英文）

基　　金：the National Natural Science Foundation of China(nos.82071939,82030051,81571689,and 81871472);Research Fellow(grant no.328933),Solutions for Health Profile(336355);InFLAMES Flagship(337531)projects from Academy of Finland,as well as the Finland China Food and Health International Pilot Project funded by the Finnish Ministry of Education and Culture;grant from Shenzhen Basic Research Program(no.JCYJ20200109114825064).

摘　　要：Rupture or erosion of inflammatory atherosclerotic vulnerable plaque is essential to acute coronary events,while the target intervene of vulnerable plaque is very challenging,due to the relatively small volume,high hemodynamic shear stress,and multifactorial nature of the lesion foci.Herein,we utilize the biological functionality of neutrophil and the versatility of microbubble in the acoustic field,to form Neu-balloon through CD11b antibody binding.The Neu-balloon inherits the advantage of neutrophils on firming the endothelium adhesion even at shear stress up to 16 dyne/cm^(2)and also maintains the acoustic enhancement property from the microbubble,to accumulate at atherosclerotic lesions under acoustic in an atherosclerotic Apo E^(-/-) mice model.Interestingly,Neo-balloon also has high and broad drug loading capacity,which enables the delivery of indocyanine green and miR-126a-5p into vulnerable plagues in vivo.Overall,the bionic Neu-balloon holds great potential to boost on-demand drug transportation into plaques in vivo.

关 键 词：BUBBLE holds utilize 

分 类 号：R54[医药卫生—心血管疾病]