Dip-Printed Microneedle Motors for Oral Macromolecule Delivery  

作　　者：Xiaoxuan Zhang Guopu Chen Lijun Cai Lu Fan Yuanjin Zhao 

机构地区：[1]Department of Rheumatology and Immunology,Nanjing Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China [2]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou 325001,China [3]Institute for Stem Cell and Regeneration,Chinese Academy of Science,Beijing 100101,China

出　　处：《Research》2022年第3期177-187,I0009,共12页研究（英文）

基　　金：the National Key Research and Development Program of China(2020YFA0908200);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16021103);the National Natural Science Foundation of China(52073060 and 61927805);the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20210324133214038).

摘　　要：Micromotors have demonstrated values in drug delivery,and recent attempts focus on developing effective approaches to generate functional micromotors to improve this area.Here,with the integration of microfluidic droplet printing and wettability-induced drawing photolithography,we present an innovative spatiotemporal serial multistep dip-printing strategy to generate novel independent microneedle motors(IMNMs)for orally delivering macromolecular drugs.As the strategy combines the advantages of the hydrophilic wettability,extension effects,and capillary effects,the IMNMs with an oblate basement and a needle-shaped head or a core-shell structured multicomponent head can be created by simply printing pregel droplets layer by layer,following with simultaneous wiredrawing and solidification.Owing to the polarized magnetic particles in the bottom basement and the rapidly dissolvable polymers as the middle basement,the resultant IMNMs can respond to magnetic fields,move to desired places under a magnet,penetrate tissue-like substrates,induce head-basement separation,and leave only the needles for cargo release.Based on these features,we have demonstrated that these IMNMs can deliver insulin via intestinal tracts to realize effective blood glucose control of diabetic rabbit models.These results indicate the practical values and bright future of the dip-printing stratagem and these IMNMs in clinical applications.

关 键 词：NEEDLE PRINTING RABBIT 

分 类 号：TH787[机械工程—仪器科学与技术]