Deciphering the dynamics of the ovarian reserve in cynomolgus monkey through a quantitative morphometric study  

利用形态计量学方法解析食蟹猴全生命周期卵巢储备变化

作　　者：Wan Tu Dongdong Ni Hua Yang Feiyan Zhao Chen Yang Xuehan Zhao Zhiyuan Guo Kunyuan Yu Jingzi Wang Zhaoshan Hu Zixuan Chen Yan Zhao Zhenbo Wang Fei Gao Long Yan Xiaokui Yang Lan Zhu Hongmei Wang 涂婉;倪冬冬;杨华;赵飞燕;杨晨;赵雪含;郭致远;于坤元;王婧子;胡肇珊;陈紫暄;赵岩;王震波;高飞;闫龙;杨晓葵;朱兰;王红梅(State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Bejing 100101,China;University of Chinese Academy of Sciences,Bejing 100049,China;Department of Gynecology and Obstetrics,Strategic Support Force Medical Center,Bejing 100101,China;Department of Obstetrics and Gynecology,National Clinical Research Center for Obstetric&Gynecologic Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing100730,China;Department of Human Reproductive Medicine,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China;Beijing Maternal and Child Health Care Hospital,Bejing 100026,China;Hebei Normal University,Shijiazhuang050024,China;Northeast Agricultural University,Harbin 150030,China;Beijing Normal University,Bejing100875,Chin;China Agricultural University,Bejing 100091,China;Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Bejing 100101,China;Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,China)

机构地区：[1]State Key Laboratory of Stem Cell and Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Bejing 100101,China [2]University of Chinese Academy of Sciences,Bejing 100049,China [3]Department of Gynecology and Obstetrics,Strategic Support Force Medical Center,Bejing 100101,China [4]Department of Obstetrics and Gynecology,National Clinical Research Center for Obstetric&Gynecologic Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing100730,China [5]Department of Human Reproductive Medicine,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China [6]Beijing Maternal and Child Health Care Hospital,Bejing 100026,China [7]Hebei Normal University,Shijiazhuang050024,China [8]Northeast Agricultural University,Harbin 150030,China [9]Beijing Normal University,Bejing100875,Chin [10]China Agricultural University,Bejing 100091,China [11]Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Bejing 100101,China [12]Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,China

出　　处：《Science Bulletin》2022年第18期1854-1859,M0003,共7页科学通报（英文版）

基　　金：supported by the National Key R&D Program of China(2018YFE0201100 and 2019YFA0110900);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16021400);CAMS Innovation Fund for Medical Sciences(2016-I2M-1-001);Beijing Hospitals Authority’Ascent Plan(DFL20191401);the National Natural Science Foundation of China(81871133)。

摘　　要：Female reproduction and health are highly dependent on ovarian function.Ovarian reserve is a critical indicator of ovarian function[1].The ovarian reserve refers to the stock of dormant primordial follicles(primordial follicle pool)residing in the ovarian cortex[2].The primordial germ cells(PGCs)are enclosed by the basal lamina to form cyst at the beginning of ovarian development[3].女性的生殖和健康与卵巢功能密切相关.卵巢储备是指卵巢内所有原始卵泡的数量(即原始卵泡库),是卵巢功能的核心指标.女性进入青春期后,卵泡的周期性募集导致原始卵泡激活,卵巢储备逐年下降,并在绝经前后耗竭.病理状态下,卵巢储备的过早耗竭导致排卵提前停止,雌激素缺乏,女性患骨质疏松症和心血管疾病的风险大大增加.对灵长类全生命周期卵巢储备变化规律的认知至关重要,但相关研究极为缺乏.由于伦理限制,健康完整的人类卵巢样品极难获得.非人灵长类与人类具有相似的遗传和生理特性,因此成为研究人类卵巢储备的理想模型.该研究利用形态计量学计数方法描绘了食蟹猴全生命周期卵巢储备的变化,并初步阐释了灵长类原始卵泡库的形成机制,为解析女性卵巢生理性衰老机制和治疗卵巢病理性衰老提供了重要理论基础.

关 键 词：卵巢储备 雌激素缺乏 形态计量学 女性卵巢 心血管疾病 全生命周期 骨质疏松症 非人灵长类 

分 类 号：R339.22[医药卫生—人体生理学]