Lower abundance of Bacteroides and metabolic dysfunction are highly associated with the post-weaning diarrhea in piglets  

作　　者：Wen Ren Bing Yu Jie Yu Ping Zheng Zhiqing Huang Junqiu Luo Xiangbing Mao Jun He Hui Yan Jinlong Wu Daiwen Chen Yuheng Luo 

机构地区：[1]Key Laboratory for Animal Disease-Resistance Nutrition of Ministry of Education of China,Key Laboratory for Animal Disease-Resistance Nutrition and Feed of Ministry of Agriculture of China,Key Laboratory of Animal Disease-resistant Nutrition of Sichuan Province,and Animal Nutrition Institute,Sichuan Agricultural University,Chengdu61l130,China [2]DSM(China)Animal Nutrition Research Center Co.,Ltd,Bazhou 065799,China

出　　处：《Science China(Life Sciences)》2022年第10期2062-2075,共14页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(31730091,31872369 and 31672436)。

摘　　要：Growing evidences show a direct link between diarrhea and disorders of gut microbiota in pigs.However,whether there are microbial markers associated with post-weaning diarrhea remains unknown.In the current study,we compared the microbial community,functions and metabolites between healthy weaned piglets(group H,n=7)and piglets with post-weaning diarrhea(group D,n=7),in order to find out diarrhea associated microbial markers.Each of 7 fecal samples was collected from H and D piglets(weaned at 21 d and sampled at 26 d).The metagenomic and untargeted metabolomic analysis revealed that the microbial composition,function and metabolic profile in D pigs was considerably reshaped,including the reduced abundance and number of Bacteroides,which significantly correlated with the diarrhea status of host.The carbohydrate metabolism,biosynthesis and metabolism,lipid metabolism,amino acid metabolism,and the activity of glycan and carbohydrates digestion related enzymes showed extensively down-regulated in D pigs compared with H pigs.Diarrhea significantly changed the metabolic profiles of fecal microbiota,and most of the altered metabolites were negatively or positively correlated with the change in the abundance of Bacteroides.In conclusion,the lower abundance of Bacteroides and its associated metabolic dysfunction may be regarded as microbial markers of physiological post-weaning diarrhea in piglets.

关 键 词：post-weaning piglet DIARRHEA BACTEROIDES metabolic dysfunction commensal microbiota 

分 类 号：S858.28[农业科学—临床兽医学]