571例皮肤软组织感染住院患者病原菌分布和耐药性分析  

Analysis of bacterial agents distribution and drug-resistance pattern in 571 skin and soft tissue infection inpatients

作　　者：张朝霞[1] 吴卫志[1] 王广进[1] 周盛基[1] 杨青[1] 颜潇潇[1] 陈明飞[1] 李富容[1] 施仲香[1] ZHANG Zhaoxia;WU Weizhi;WANG Guangjin;ZHOU Shengji;YANG Qing;YAN Xiaoxiao;CHEN Mingfei;LI Furong;SHI Zhongxiang(Shandong Provincial Hospital for Skin Disease&Shandong Provincial Institute of Dermatology and Venereology,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250022,China)

机构地区：[1]山东第一医科大学附属皮肤病医院(山东省皮肤病医院),山东省皮肤病性病防治研究所,济南250022

出　　处：《中国麻风皮肤病杂志》2022年第11期775-779,共5页China Journal of Leprosy and Skin Diseases

基　　金：山东省医药卫生科技发展计划项目(编号:202004120207)。

摘　　要：目的:研究我院住院患者中皮肤软组织感染者(SSTI)病原菌分布及耐药性。方法:收集571例我院2018年1月1日至2020年12月31日SSTI病原培养结果阳性的住院患者,分析病原菌分布特点以及主要革兰氏阳性优势菌的耐药情况。结果:患者按病种分类,主要有天疱疮、大疱性类天疱疮、湿疹、银屑病等。571例SSTI患者共培养菌株624株,革兰氏阳性菌529株(占84.8%),革兰氏阴性菌76株(占12.1%),真菌19株(占3.0%);主要优势菌为金黄色葡萄球菌、溶血葡萄球菌、中间葡萄球菌,均对青霉素、红霉素、阿奇霉素明显耐药,对米诺环素和替考拉宁敏感性均为100%。结论:金黄色葡萄球菌、溶血葡萄球菌、中间葡萄球菌为我院SSTI最主要致病菌。革兰氏阳性优势菌对青霉素、红霉素、阿奇霉素等耐药率高,对米诺环素、多西环素、替考拉宁、利奈唑胺等耐药率较低,可以指导临床用药。Objective:To investigate the bacterial agents distribution and drug-resistance pattern in inpatients of skin and soft tissue infections(SSTI).Methods:A total of 571 SSTI patients with positive germiculture results were selected from our hospital from January 1,2018 to December 31,2020.Analyze the distribution characteristics of pathogenic bacteria in different diseases and drug resistance of dominant Gram-positive bacteria.Results:According to disease classification,there were pemphigus,bullous pemphigus,eczema,psoriasis,etc.A total of 624 strains were cultured in 571 SSTI patients,including 529 Gram-positive strains(84.8%),76 Gram-negative strains(12.1%)and 19 fungal strains(3.0%).The main dominant bacteria were Staphylococcus aureus,Staphylococcus haemolyticus and Staphylococcus intermediatus,which were significantly resistant to penicillin,erythromycin and azithromycin,and the sensitivity to minocycline and teicoranin were 100%.Conclusion:Staphylococcus aureus was the most important pathogen in SSTI,Gram-positive dominant bacteria had high drug resistance rate to penicillin,azithromycin and erythromycin,and high sensitivity to minocycline,doxycycline,teicoranin and linezolid,which could guide clinical medication.

关 键 词：皮肤软组织感染 细菌培养 药敏试验 耐药率 

分 类 号：R446.5[医药卫生—诊断学] R632[医药卫生—临床医学]