压缩感知实时成像结合回顾性运动校正心脏磁共振电影序列对评估肺动脉高压患者右室功能及应变的应用价值  

Application value of cardiac cine with compressed sensing real-time imaging and retrospective fully automated non-rigid motion correction for assessment of right ventricular function and strain in patients with pulmonary arterial hypertension

作　　者：李颜玉 林路[1] 王健[1] 曹立坤 刘亚静 庞加宁 安靖 金征宇[1] 王怡宁[1] LI Yanyu;LIN Lu;WANG Jian;CAO Likun;LIU Yajing;PANG Jianing;AN Jing;JIN Zhengyu;WANG Yining(Department of Radiology,Peking Union Medical College Hospital of Chinese Academy of Medical Sciences,Beijing 100730,China;Siemens Medical Solutions USA Inc.,Chicago,IL USA;Siemens Shenzhen Magnetic Resonance Ltd.,Shenzhen 518057,China)

机构地区：[1]中国医学科学院北京协和医院放射科,北京100730 [2]西门子(美国)医疗系统有限公司,芝加哥 [3]西门子(深圳)磁共振有限公司,深圳518057

出　　处：《磁共振成像》2022年第10期114-120,共7页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金重点国际合作研究项目(编号:82020108018);北京市自然科学基金重点研究专题项目(编号:Z210013);中国医学科学院医学与健康科技创新工程项目(编号:2020-I2M-C&T-B-034)。

摘　　要：目的探讨一种结合压缩感知、高速实时成像及回顾性全自动非刚性运动校正技术的自由呼吸心脏磁共振电影(cardiac cine with compressed sensing real-time imaging and retrospective fully automated non-rigid motion correction,cine-MoCo)序列对肺动脉高压(pulmonary arterial hypertension,PAH)患者右室(right ventricular,RV)功能及应变评估的应用价值。材料与方法前瞻性连续纳入2020年1月至2021年4月于中国医学科学院北京协和医院放射科进行心脏磁共振(cardiac magnetic resonance,CMR)检查的疑诊或确诊PAH患者。对所有纳入患者均完成标准的2D分段采集结合回顾性心电门控电影序列(2D segmented cine imaging with retrospective ECG gating,cine-SegBH)及cine-MoCo图像采集,对两种电影序列采集的图像进行图像质量评价、RV功能及应变定量分析。结果40例患者纳入本次研究。cine-SegBH与cine-MoCo的图像采集时间分别为(143±42)s及(115±24)s,差异具有统计学意义(P<0.05)。cine-MoCo获取的电影图像质量在主观评价(5分标准)及欧洲CMR质量评估标准评价中优于cine-SegBH,差异具有统计学意义(P均<0.05)。图像边缘锐利度测量结果显示,cine-SegBH与cine-MoCo相当,差异无统计学意义(P>0.05)。cine-MoCo在RV功能[RV射血分数(right ventricular ejection fractions,RVEF),RV舒张末期容积(right ventricular end-diastolic volumes,RVEDV),RV收缩末期容积(right ventricular end-systolic volumes,RVESV),RV每搏输出量(right ventricular stroke volumes,RVSV)及RV心肌质量(right ventricular mass,RVM)]定量分析中,与cine-SegBH获取的对应结果均存在强的相关性(r=0.966~0.992),且差异无统计学意义(P均>0.05)。RV心肌应变[纵向应变(global longitudinal strain,GLS)、周向应变(global circumferential strain,GCS)及径向应变(global radial strain,GRS)]定量评价中,两电影序列在GCS及GRS评价中存在强的相关性(GCS:r=0.895;GRS:r=0.908),GLS存在弱的相关性(r=0.564),且cine-MoCo获�Objective:To evaluate the feasibility and accuracy of free-breathing cardiac cine MR imaging(cine-MoCo)combined with compressed sensing,highly accelerated real-time acquisition,and retrospective fully automated non-rigid motion correction for right ventricular(RV)function and strain analysis in patients with pulmonary arterial hypertension(PAH).Materials and Methods:Suspected or confirmed PAH patients clinically scheduled for CMR assessment were enrolled in Department of Radiology of Peking Union Medical College Hospital of Chinese Academy of Medical Sciences from January 2020 to April 2021.All enrolled patients received the standard cine imaging with 2D segmented acquisition and retrospective ECG gating(cine-SegBH)and cine-MoCo.Image quality(IQ)was evaluated using a qualitative 5-point Likert scale and the European CMR registry standardized criteria,and edge sharpness was measured.RV function and strain were measured and compared.Results:Forty patients were enrolled in this study.The mean scan times of cine-SegBH and cine-MoCo were(143±42)s and(115±24)s,respectively(P<0.05).The general subjective IQ scores of cine-MoCo and cine-SegBH were(4.4±0.7)and(4.1±0.8),respectively(P<0.05),and the standardized criteria IQ scores of cine-MoCo and cine-SegBH based on the European CMR registry standardized criteria were(0.125±0.404)and(0.425±0.844),respectively(P<0.05).There was no significant difference by edge sharpness measurement between cine-SegBH and cine-MoCo[(0.064±0.133)vs.(0.065±0.139),P>0.05].There were no significant differences in the assessment of RV functional parameters between cine-SegBH and cine-MoCo,including RV ejection fraction(RVEF),RV end-diastolic volume(RVEDV),RV end-systolic volume(RVESV),RV stroke volumes(RVSV),and RV mass(RVM),additionally,all RV functional parameters showed strong correlations(r=0.966-0.992)between the two cine techniques.RV myocardial strain including global longitudinal strain(GLS),global circumferential strain(GCS),and global radial strain(GRS)derived from cine-MoCo we

关 键 词：肺动脉高压 心肌应变 心功能分析 运动校正 磁共振成像 心脏磁共振电影成像 压缩感知 

分 类 号：R445.2[医药卫生—影像医学与核医学] R543.2[医药卫生—诊断学]