复发性与首发性抑郁症杏仁核静息态功能连接的对比研究  

Comparative study on resting functional connection of amygdala between recurrent and first-episode depression

作　　者：孙继飞 马跃 郭春蕾 罗屹 高山山 陈庆燕 洪洋[2] 张国雷 方继良[1] SUN Jifei;MA Yue;GUO Chunlei;LUO Yi;GAO Shanshan;CHEN Qingyan;HONG Yang;ZHANG Guolei;FANG Jiliang(Functional Brain imaging Lab,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Department of Radiology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院功能成像室,北京100053 [2]中国中医科学院广安门医院放射科,北京100053

出　　处：《磁共振成像》2022年第10期144-149,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金面上项目(编号:82174282、81774433);科技部国家重点研发计划(编号:2018YFC1705802);中国中医科学院科技创新工程项目(编号:CI2021A03301)。

摘　　要：目的通过对比复发性抑郁症(recurrent depressive episodes,RDE)与首发性抑郁症(first depressive episode,FDE)杏仁核静息态功能连接(functional connectivity,FC)差异,以探索RDE的FC改变特征。材料与方法前瞻性纳入RDE患者、FDE患者及健康对照者(healthy controls,HCs)各21例,采集3组受试者静息态脑功能MRI数据,并完成临床抑郁、焦虑及冗思等量表的评定。采用单因素方差分析比较3组双侧杏仁核与全脑FC差异,并对结果进行高斯随机场校正。提取3组间FC有差异脑区的时间序列均值(FC值),对FC值进行事后两两比较,所得结果进行Bonferroni校正(P<0.016)。最后对3组间差异有统计学意义的脑区的FC值与临床量表评分进行Pearson相关分析。结果(1)与FDE组比较,RDE组左侧杏仁核与左、右侧前扣带回/左侧眶部额上回的FC增强,RDE组右侧杏仁核与右侧中央前回/右侧楔前叶、右侧补充运动区/右侧中扣带回的FC增强。与HC组比较,RDE组左侧杏仁核与左、右侧前扣带回/左侧眶部额上回的FC增强。(2)RDE组左侧杏仁核与左、右侧前扣带回/左侧眶部额上回的FC值与中文版冗思量表(Rumination Response Scale,RRS)评分呈正相关(r=0.460,P=0.033)。结论RDE与FDE在杏仁核与边缘神经环路、奖赏环路、体感运动区及默认网络的FC值存在差异,且RDE存在更为广泛的FC改变特征,这可能是RDE神经病理机制更为复杂的原因。Objective:To explore the functional connectivity(FC)alterations in RDE by comparing the resting-state FC differences in amygdala in recurrent depressive episodes(RDE)and first depressive episode(FDE)characteristics.Materials and Methods:Twenty-one patients with RDE,patients with FDE,and healthy controls(HCs)were included,and resting-state brain function MRI data were collected from the 3 groups of subjects,and clinical depression,anxiety,and redundancy scales were completed.One-way ANOVA was used to compare the differences between bilateral amygdala and whole brain FC in the 3 groups,and the results were corrected for Gaussian random fields.Time series means(FC values)of the brain regions with differences in FC between the 3 groups were extracted and the results were Bonferroni corrected(P<0.016)for post hoc two-by-two comparisons of FC values.Finally,Pearson correlation analysis was performed between FC values and clinical scale scores for the statistically different brain regions among the 3 groups.Results:(1)Compared with the FDE group,the FC of the left amygdala with the left and right anterior cingulate gyrus/left orbital part of the superior frontal gyrus was increased in the RDE group,and the FC of the right amygdala with the right precentral gyrus/right precuneus and right supplementary motor area/right middle cingulate gyrus was increased in the RDE group.Compared with the HC group,the FC of the left amygdala with the left and right anterior cingulate gyrus/left orbital part of the superior frontal gyrus was increased in the RDE group.(2)The FC values of the left amygdala and the left and right anterior cingulate/left orbital part of the superior frontal gyrus in the RDE group were positively correlated with the Rumination Response Scale(RRS)scores(r=0.460,P=0.033).Conclusions:There were differences in FC between RDE and FDE in the amygdala and limbic circuits,reward circuit,somatosensory-motor areas and default mode network,and a more extensive FC alteration feature was present in RDE,which may be the r

关 键 词：复发性抑郁症 首发性抑郁症 杏仁核 静息态 磁共振成像 功能连接 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.3[医药卫生—诊断学]