血管壁干细胞与血管重塑相关性疾病  

Vascular wall stem cells and vascular remodeling-related diseases

作　　者：曹雪洁 陶佳平 曲爱娟[1] 于宝琪 CAO Xuejie;TAO Jiaping;QU Aijuan;YU Baoqi(Department of Physiology and Pathophysiology,School of Basic Medicine,Capital Medical University&Key Laboratory of Remodeling-related Cardiovascular Diseases,Ministry of Education,Beijing 100069,China)

机构地区：[1]首都医科大学基础医学院生理学与病理生理学系重塑相关心血管疾病教育部重点实验室,北京市100069

出　　处：《中国动脉硬化杂志》2022年第11期921-929,共9页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金资助项目(81870186);北京市自然科学基金B类重点项目(KZ201910025027);北京市属高校高水平教师队伍建设支持计划青年拔尖人才项目(CIT&TCD201904090);北京市属高校高水平教师队伍建设支持计划长城学者培养计划(CIT&TCD20190332)。

摘　　要：血管重塑是动脉粥样硬化等多种心血管疾病的病理生理学基础,血管壁中多种细胞均在该过程中发挥重要作用。其中血管壁干细胞作为一类存在于血管壁中的成体干细胞,既在机体生长发育及成年早期阶段参与血管新生,也可在成年后受致病因素影响,从休眠状态中激活,向内皮细胞、平滑肌细胞等方向分化,参与血管损伤后重塑,从而影响相关疾病的进程。文章对血管壁干细胞在血管重塑相关性疾病的最新进展进行综述,为进一步展示血管壁干细胞可能具有治疗潜力提供依据。Vascular remodeling is the pathophysiological basis of many cardiovascular diseases such as atherosclerosis, and various cells in the blood vessel wall play an important role in this process. Among them, vascular wall stem cells, as a type of adult stem cells that exist in the vascular wall, not only participate in angiogenesis during the growth and development of the body and early adulthood, but also can be affected by pathogenic factors in adulthood, activate from dormant state, differentiate into endothelial cells and smooth muscle cells, participate in vascular remodeling after vascular injury, and affect the process of related diseases. This paper reviews the latest progress of vascular wall stem cells in vascular remodeling-related diseases, so as to provide a basis for further demonstrating the possible therapeutic potential of vascular wall stem cells.

关 键 词：血管壁干细胞 血管重塑 血管重塑相关性疾病 动脉粥样硬化 内皮细胞 血管平滑肌细胞 

分 类 号：R543[医药卫生—心血管疾病]