5-溴嘧啶基苯衍生物的合成  

Sythesis of 5-bromopyridylbenzene derivatives

作　　者：郑爱助 曾旺 金武松[1] 李贤英[2] 张灯青[1] ZHENG Ai-zhu;ZENG Wang;JIN Wu-song;LI Xian-ying;ZHANG Deng-qing(College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China;College of Environment Science and Engineering,Donghua University,Shanghai 201620,China)

机构地区：[1]东华大学化学化工与生物工程学院,上海201620 [2]东华大学环境科学与工程学院,上海201620

出　　处：《应用化工》2019年第S01期42-44,48,共4页Applied Chemical Industry

基　　金：上海市科委科技创新行动计划基础研究(NO.16 JC1401900)。

摘　　要：以4-甲基苯磺酸-1-十二酯和4-甲基苯磺酸(3-(十二烷氧基)-2-(十二烷氧基)甲基)丙酯为起始原料和3-溴苯酚通过取代反应合成相应的醚类化合物3和4。化合物3和4再和双频哪醇合二硼在[Ir(OMe)cod]_(2)、dtbpy的催化下合成化合物5和6,最后再和5-溴-2-碘嘧啶发生Suzuki-Miyaura交叉偶联反应得到化合物7和8,通过^(1)H NMR、^(13)C NMR和MALDI-TOF Mass对它们进行了表征。Ether compounds 3 and 4 were synthesized by substitution reaction of sulfonate compounds 1 and 2 with 3-bromophenol.Which were further treated with bis(pinacolato)diboron under[Ir(OMe)cod]_(2) and dtbpy catalysis to give compounds 5 and 6,finally,compounds 7 and 8 were prepared by Pa(0) catalyzed Suzuki-Miyaura coupling reaction of 5-bromo-2-iodopyrimidine with compounds 5 and 6.They were characcterized by ^(1)H NMR,^(13)C NMR,and MADIL-TOF mass.

关 键 词：3-溴苯酚 3-溴-5-十二烷氧基苯硼酸酯 [Ir(OMe)cod]_(2) dtbpy催化 Suzuki-Miyaura交叉偶联反应 表征 

分 类 号：O625.6[理学—有机化学]