新型烟酰胺-铕配合物的合成及性能研究  

Synthesis and Properties of A Novel Nicotinamide-Europium Complex

作　　者：吉燕华 江文琳 高薇 孙心瑗[3] 郭奇峰 杨清泉 沈华翔 曾治君[2] JI Yanhua;JIANG Wenlin;GAO Wei;SUN Xinyuan;GUO Qifeng;YANG Qingquan;SHEN Huaxiang;ZENG Zhijun(Laboratory Animal Science and Technology Center,University of Jiangxi Traditional Chinese Medicine,Nanchang 330004,China;Research Center for Differentiation and Development of Traditional Chinese Medicine Basic Theory,University of Jiangxi Traditional Chinese Medicine,Jiangxi Province Key Laboratory of Traditional Chinese Medicine Etiopathogenisis,Nanchang 330004,China;College of Mathematics,Jinggangshan University,Ji’an 343009,China)

机构地区：[1]江西中医药大学实验动物科技中心,江西南昌330004 [2]江西中医药大学中医基础理论分化发展研究中心江西省中医病因生物学重点实验室,江西南昌330004 [3]井冈山大学数理学院,江西吉安343009

出　　处：《合成化学》2022年第10期765-770,共6页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(81760787);江西省中医药中青年骨干人才项目(赣中医药科教字〔2021〕2号);江西省卫计委科技计划(20203772)。

摘　　要：以烟酰胺和硝酸铕为原料,采用热溶剂法合成了烟酰胺-铕配合物的微纳米球。其结构和性能经红外光谱(IR)、热重(TG)、扫描电镜(SEM)、X-射线衍射(XRD)、元素分析(EDS)和荧光检测等表征。研究结果表明:配合物含有碳、氧、氮和铕等元素,其红外光谱图与烟酰胺配体有明显的差异;配合物的质量在250℃和550℃条件下出现了明显的下降,下降率分别为15%和19%;SEM照片显示配合物为大小不均一的微纳米球,且具有较好的荧光发光性能,发射峰位于579 nm,591 nm,612 nm,618 nm,693 nm和699 nm。烟酰胺配体和烟酰胺-铕配合物对肺癌人肺泡基底上皮细胞(A549细胞)的活性影响趋势一致,随着药物浓度升高,该细胞活性没有发生明显变化。Nicotinamide and europium nitrate are used as raw materials to synthesize nicotinamide-europium complexes and characterize them.The micro-nano-spherical complexes were obtained by the hot solvent method.We used infrared,thermogravimetric,SEM,XRD,EDS and fluorescence detection to characterize and analyze the complex.The results show that the synthesized complex contains C,O,N,Eu and other elements,and its infrared spectrum is significantly different from the nicotinamide ligand.The mass of the complex decreased significantly at 250℃and 550℃by 15%and 19%,respectively.SEM images showed that the complexes were nanospheres of uneven size,with good fluorescence luminescence performance and emission peaks at 579 nm,591 nm,612 nm,618 nm,693 nm and 699 nm.The results of cell experiments showed that the effects of nicotinamide ligand and nicotinamide europium complex on the activity of A549 cells(epithelial cells of human alveolar adenocarcinoma base)were consistent,and the activity of A549 cells did not change significantly with the increase of drug concentration.

关 键 词：烟酰胺 硝酸铕 热溶剂法 合成 微纳米球 荧光 细胞实验 

分 类 号：Q517[生物学—生物化学] O62[理学—有机化学]