生物3D打印PLCL/PPDO基骨修复支架  

3D Bioprinting PLCL/PPDO Based Bone Repair Scaffold

作　　者：杜雨寒 侯培杰 邢璐瑶 刘锡亮 陈栋梁[1,2] 熊成东 张丽芳[1,2] DU Yuhan;HOU Peijie;XING Luyao;LIU Xiliang;CHEN Dongliang;XIONG Chengdong;ZHANG Lifang(Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu 610041,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院成都有机化学研究所,四川成都610041 [2]中国科学院大学,北京100049

出　　处：《合成化学》2022年第10期797-802,共6页Chinese Journal of Synthetic Chemistry

基　　金：中国江苏省科技支撑计划项目(BE2018647)。

摘　　要：通过生物3D打印将聚L-丙交酯-己内酯PLCL(摩尔比:LLA/CL=90/10)和聚对二氧环己酮PPDO共混物制备成平均孔径约为500μm,孔隙率为60%的骨修复支架,并进行了15 w的降解实验。通过DSC测试分析材料和支架的热力学性能;通过SEM照片分析骨修复支架。结果表明:PPDO的加入明显缩短了PLCL/PPDO复合支架的降解时间;当支架中PPDO的含量超过10%时,PLCL和PPDO的相容性越差,支架表面的粗糙程度越高,且支架内部相分离越明显。A blend of poly-L-propylene-caprolactone PLCL(molar ratio:LLA/CL=90/10)and poly-p-dioxanone PPDO was prepared by bio-3D printing to form a bone repair scaffold with an average pore size of approximately 500μm and 60%porosity.Degradation experiments were also carried out for 15 weeks.The thermomechanical properties of the materials and scaffolds were analysed by DSC tests.SEM images of the scaffolds showed that when the content of PPDO in the scaffold exceeded 10%,the compatibility between PLCL and PPDO gradually became worse and worse,the roughness of the scaffold surface became higher and the phase separation inside the scaffold became more obvious.The results of degradation experiments showed that the addition of PPDO significantly accelerated the degradation time of PLCL/PPDO composite scaffold.

关 键 词：PLCL/PPDO 生物3D打印 生物可降解 加速降解 骨修复 

分 类 号：O621.3[理学—有机化学]