烯烃叠氮化和芳基化合成吲哚啉酮衍生物  

Synthesis of Indolinone Derivatives via Azidation and Arylation of Alkenes

作　　者：张杰 卢欣 姚媛璐 石亮亮 ZHANG Jie;LU Xin;YAO Yuanlu;SHI Liangliang(Tianjin Lisheng Pharmaceutical Co.,Ltd.,Tianjin 300380,China)

机构地区：[1]天津力生制药股份有限公司,天津300380

出　　处：《合成化学》2022年第10期827-833,共7页Chinese Journal of Synthetic Chemistry

基　　金：天津市科技计划项目(课题)技术创新引导专项基金资助项目(17YDLJSY00080)。

摘　　要：以廉价、易得的N-烷基-N-芳基甲基丙烯酰胺衍生物为起始原料,叠氮化钠为叠氮源,碘苯二乙酸为氧化剂,1,2-二氯乙烷为溶剂,合成了吲哚啉酮衍生物。该反应经历了无过渡金属催化烯烃的芳基化和叠氮化。目标化合物结构经^(1)H NMR,^(13)C NMR和MS(ESI)表征。Indolinone derivatives were synthesized from readily available N-alkyl-N-phenylalkacrylamides as starting materials,sodium azide as the azido source,iodiphenylacetic acid as the oxidant agent and 1,2-dichloroethane as the solvent,respectively.The procedure underwent metal-free domino azidation and arylation of alkenes.The target compound was charactererized by ^(1)H NMR,^(13)C NMR and MS(ESI).

关 键 词：无金属反应 多米诺反应 吲哚啉酮 叠氮化 芳基化 合成 

分 类 号：O626.1[理学—有机化学]