地诺孕素与优思明治疗子宫内膜异位症术后患者的疗效比较  

Comparison of efficacy of desorgestrel and yasmin in patients with endometriosis after surgery

作　　者：周娜 Zhou Na(Department of Obstetrics and Gynecology,Macheng Maternal and Child Health Hospital,Huanggang 438300,China)

机构地区：[1]麻城市妇幼保健院妇产科,湖北黄冈438300

出　　处：《实用妇科内分泌电子杂志》2022年第12期95-97,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的分析子宫内膜异位症(EMs)患者术后口服地诺孕素与屈螺酮烘雌醇片(优思明)的临床疗效。方法选取100例行保守手术治疗的EMs患者,采用随机数字表法将其分为对照组与研究组,每组50例。对照组患者采用优思明治疗,研究组患者采用地诺孕素治疗。比较两组患者临床疗效。结果服药前,两组患者月经量和视觉模拟评分法(VAS)评分对比,差异无统计学意义(P>0.05);服药6个月,研究组月经量少于对照组,VAS评分低于对照组,差异有统计学意义(P<0.05)。服药前,两组患者子宫体积和癌抗原125(CA125)水平对比,差异无统计学意义(P>0.05);服药6个月,研究组子宫体积小于对照组,CA125水平低于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率为10.0%,显著低于对照组的32.0%,差异有统计学意义(P<0.05)。结论与优思明相比,地诺孕素应用于EMs术后维持治疗,可显著提升临床疗效,降低不良反应发生率,值得临床推广与应用。Objective To analyze the clinical efficacy of oral administration of denorgestrel and drospirenone ethinylestradiol tablets(Yasmin)in patients with endometriosis(EMs)after operation.Methoeds 100 EMs patients undergoing conservative surgery were selected and divided into control group and study group by random number table method,with 50 cases in each group.Patients in the control group were treated with Yasmin,and patients in the study group were treated with desorgestrel.The clinical efficacy of the two groups was compared.Results Before medication,there was no significant difference in menstrual volume and visual analogue scale(VAS)score between the two groups(P>0.05).After 6 months of medication,the menstrual volume of the study group was less than that of the control group,and the VAS score was lower than that of the control group,and the differences were statistically significant(P<0.05).Before medication,there was no significant difference in uterine volume and CA125 level between the two groups(P>0.05).After 6 months of medication,the uterine volume of the study group was smaller than that of the control group,and the CA125 level was lower than that of the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the study group was 10.0%,which was significantly lower than 32.0% in the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with Yosmin,denorgestrel can significantly improve the clinical efficacy and reduce the incidence of adverse reactions in postoperative maintenance treatment of EMs,which is worthy of clinical promotion and application.

关 键 词：子宫内膜异位症 地诺孕素 屈螺酮炔雌醇片 临床疗效 

分 类 号：R713.4[医药卫生—妇产科学]