雄激素及其受体在慢性肾脏病相关的血管钙化中的研究进展  

Research advances of androgen and androgen receptor in vascular calcification of chronic kidney disease

作　　者：庞海燕[1] Pang Haiyan(Department of Kidney Disease Blood Purification,Tianjin Medical University Second Hospital,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院肾脏病血液净化科,300211

出　　处：《国际内分泌代谢杂志》2022年第5期387-390,400,共5页International Journal of Endocrinology and Metabolism

基　　金：天津市自然科学基金(19JCYBJC24900)。

摘　　要：血管钙化是慢性肾脏病(CKD)的常见并发症,是CKD患者心血管事件增加的危险因素之一。CKD血管钙化的发病机制目前尚未完全明确,可能涉及多种病理生理过程如炎症反应、细胞凋亡、氧化应激、低氧反应等。CKD血管钙化中男性发病率显著高于女性,提示雄激素可能在CKD血管钙化的发展过程中发挥重要作用。本文对雄激素及雄激素受体与CKD血管钙化的相关性研究进行综述。Vascular calcification is a common complication of chronic kidney disease(CKD),and is one of the risk factors for increased cardiovascular events in CKD.The pathogenesis of CKD vascular calcification is not fully clarified,and various pathophysiological processes such as inflammatory response,apoptosis,oxidative stress and hypoxic response may be the underlying reasons.The incidence of CKD vascular calcification is significantly higher in men than in women,showing that androgen may play an important role in the development of CKD vascular calcification.In this paper,the relevant studies of androgen and its receptor in CKD vascular calcification were reviewed in order to provide new ideas for deeply understanding the regulatory mechanism of CKD vascular calcification and seeking new targets for the treatment of CKD vascular calcification.

关 键 词：雄激素 雄激素受体 血管钙化 慢性肾脏病 

分 类 号：R692[医药卫生—泌尿科学]