社区人群晨尿1-溴丙烷代谢产物与外周血液参数的关联  

Associations of morning urinary 1-bromopropane metabolite with peripheral blood parameters in a community-based population

作　　者：梁如意 樊烈阳 杨世杰 刘伟 余林玲 王彬 陈卫红[1] LIANG Ruyi;FAN Lieyang;YANG Shijie;LIU Wei;YU Linling;WANG Bin;CHEN Weihong(Department of Occupational and Environmental Health/Key Laboratory of Environment and Health,Ministry of Education&Ministry of Environmental Protection/State Key Laboratory of Environmental Health(Incubating),School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030)

机构地区：[1]华中科技大学同济医学院公共卫生学院,劳动卫生与环境卫生学系/环境与健康教育部重点实验室/国家环境保护环境与健康重点实验室,湖北武汉430030

出　　处：《环境与职业医学》2022年第7期737-744,共8页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金重大研究计划集成项目(91843302);中国博士后科学基金(2021M691131)。

摘　　要：[背景]环境污染物1-溴丙烷广泛存在于生活环境中,但其对一般人群的健康影响仍不明确。[目的]评估社区人群尿1-溴丙烷代谢产物与血常规指标的关联。[方法]以武汉-珠海队列基线的3512名18~80岁社区成年居民为研究对象,通过问卷调查收集人口学基本特征、疾病史以及生活习惯等相关信息,体格检查测定身高、体重和血压等指标,使用全自动血液分析仪测定血常规指标,并应用超高效液相色谱耦合电喷雾串联质谱仪检测晨尿中1-溴丙烷代谢产物N-乙酰基-S-(正丙基)-L-半胱氨酸(BPMA)。采用广义线性模型和logistic回归模型分析尿BPMA浓度与血常规指标及其异常情况的关联,进一步按照个体因素和生活方式分层,分析不同亚组尿BPMA浓度与血常规指标的关联,并且探究各分层变量对上述关联的效应修饰作用。所有模型均校正了性别和年龄等混杂因素。[结果]研究对象年龄为(52.78±12.77)岁,男性占30.1%。尿BPMA经尿肌酐校正后的中位数(M)及第25、75百分位数(P_(25),P_(75))浓度为0.90(0.50,1.73)mg·mol^(-1)。连续性数据分析显示,尿BPMA浓度自然对数转换值每增加1个单位,白细胞数、淋巴细胞数、淋巴细胞百分比、平均血红蛋白浓度和血小板数分别减少0.078×10^(9) L^(-1)、0.031×10^(9) L^(-1)、0.307%、3.518 g·L^(-1)和2.469×10^(9) L^(-1)(均P<0.05);红细胞比容和平均红细胞体积水平分别增加0.440%和1.140 fL(均P<0.05);平均血小板体积和平均血小板体积与血小板计数比值的自然对数转换值分别增加0.014 fL和0.020(均P<0.05)。以BPMA为四分位等级变量分析发现,尿BPMA与淋巴细胞百分比、平均血红蛋白浓度和血小板数呈负向剂量-效应关系(均P_(trend)<0.05);与红细胞比容、平均红细胞体积、平均血小板体积和平均血小板体积与血小板计数比值呈现正向剂量-效应关系(均P_(trend)<0.05)。体重指数、吸烟和饮酒修饰了尿B[Background]As an environmental pollutant,1-bromopropane(1-BP)is ubiquitous in the living environment.However,its health effects on the general population are still unclear.[Objective]To assess the associations between urinary 1-BP metabolite and blood routine indices in a Chinese community population.[Methods]A total of 3512 community residents aged 18-80 years from the baseline of the Wuhan-Zhuhai cohort were included in our study.The demographic characteristics,disease history,and lifestyles of the participants were collected through questionnaires.Height,weight,blood pressure,and other anthropometrics were collected through physical examination.Blood routine indicators were tested using an automated hematology analyzer.Urinary 1-BP metabolite N-Acetyl-S-(n-propyl)-L-cysteine(BPMA)was measured by ultra-high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.Generalized linear models and logistic regression models were used to assess the associations of urinary BPMA with blood routine indices and the risks of abnormal blood routine indices,respectively.Besides,stratified analysis and effect modification analysis were further conducted to investigate the effects of individual characteristics and lifestyles on the associations of urinary BPMA with blood routine indices.All models were adjusted for gender,age,and other potential confounders.[Results]The mean age of the study population(30.1%male)was(52.78±12.77)years.The median(P_(25),P_(75))level of urinary BPMA adjusted for urinary creatinine was 0.90(0.50,1.73)mg·mol^(−1).In the analysis with target indicator as continuous variable,each 1-unit increase in natural logarithm-transformed urinary BMPA level was associated with a 0.078×10^(9) L^(-1),0.031×10^(9) L^(-1),0.307%,3.518 g·L^(-1),and 2.469×10^(9) L^(-1) decrease in white blood cell,lymphocyte,lymphocyte percentage,mean corpuscular hemoglobin concentration,and platelet levels,respectively(all Ps<0.05);and with a 0.440%,1.140 fL,0.014 fL,and 0.020 increas

关 键 词：1-溴丙烷 N-乙酰基-S-(正丙基)-L-半胱氨酸 血常规指标 血液毒性 横断面研究 

分 类 号：R12[医药卫生—环境卫生学]