环境内分泌干扰化学物诱发的生殖毒性和生殖系统肿瘤的研究进展  

Research progress on reproductive toxicity and reproductive system tumors induced by environmental endocrine disrupting chemicals

作　　者：刘佳豪 金英姬[4] 魏琴琴 金祉延 韦妲 金玉姬 LIU Jiahao;JIN Yingji;WEI Qinqin;JIN Zhiyan;WEI Da;JIN Yuji(Department of Laboratory Medicine,Jilin Medical University,Jilin,Jilin 132013,China;Department of Clinical Medicine,Jilin Medical University,Jilin,Jilin 132013,China;Department of Basic Medicine,Jilin Medical University,Jilin,Jilin 132013,China;Department of Dermatology,Yanbian University Hospital,Yanji,Jilin 133000,China;Department of Agriculture,Yanbian University,Yanji,Jilin 133000,China)

机构地区：[1]吉林医药学院检验学院,吉林吉林132013 [2]吉林医药学院临床医学院,吉林吉林132013 [3]吉林医药学院基础医学院,吉林吉林132013 [4]延边大学附属医院皮肤科,吉林延吉133000 [5]延边大学农学院,吉林延吉133000

出　　处：《环境与职业医学》2022年第7期833-839,共7页Journal of Environmental and Occupational Medicine

基　　金：吉林市医疗卫生指导性计划(201900991);吉林省大学生创新训练项目(s202113706041)。

摘　　要：环境内分泌干扰化学物是一类普遍存在于环境中的外源性化学物质,进入机体后可干扰内分泌稳态,对机体的生殖、免疫、神经等功能产生不利影响,其中对生殖系统的损害最为显著。研究证实机体长期暴露于环境内分泌干扰化学物会对原始生殖细胞生长、生殖器官发育、生殖内分泌调节等产生不可逆有害影响,且与各种生殖系统肿瘤的发生发展也具有明显的相关性。本文综述了常见的环境内分泌干扰化学物在发育期和生殖期所诱发的各种生殖毒性及其在生殖系统肿瘤中发生发展的作用机制。Environmental endocrine disrupting chemicals are a kind of exogenous chemicals that generally exist in the environment,and can disturb the endocrine homeostasis and adversely affect reproductive,immune,neurological,and other functions after entering the body,among which the damage to the reproductive system is the most significant one.Studies have confirmed that the long-term exposure to environmental endocrine disrupting chemicals have irreversible and harmful effects on primordial germ cell growth,reproductive organ development,and reproductive endocrine regulation,and also have obvious correlations with the occurrence and development of various reproductive system tumors.This paper reviewed various reproductive toxicities induced by common environmental endocrine disrupting chemicals in the developmental and reproductive stages,and associated mechanisms involved in the occurrence and development of reproductive system tumors.

关 键 词：环境内分泌干扰物 双酚A 多氯联苯 邻苯二甲酸酯 壬基苯酚 生殖毒性 生殖系统肿瘤 

分 类 号：R12[医药卫生—环境卫生学]