脉络宁注射液在下肢动脉硬化闭塞症中对血液循环的改善及对血管内皮的影响  

Effect of Mailuoning injection on blood circulation and vascular endothelium in patients with lower extremity arteriosclerosis obliterans

作　　者：康海涵 李飞[1] 吴成稳[1] 崔文军[2] KANG Hai-han;LI Fei;WU Cheng-wen;CUI Wen-jun(Department of Vascular Surgery,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450000,China;不详)

机构地区：[1]郑州大学第二附属医院血管外科,河南郑州450000 [2]郑州大学第五附属医院血管外科

出　　处：《中华全科医学》2022年第10期1658-1661,共4页Chinese Journal of General Practice

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ 20190420)。

摘　　要：目的探讨脉络宁注射液在下肢动脉硬化闭塞症(ASO)中对血液循环的改善及对血管内皮的影响。方法纳入2018年1月—2020年1月在郑州大学第二附属医院就诊的下肢ASO患者104例,按照随机数字表法分为对照组(52例)和观察组(52例)。对照组采用前列地尔治疗,观察组采用前列地尔联合脉络宁治疗。比较治疗前后2组血液流变学指标、黏附因子、炎症因子水平,比较2组的近期临床疗效及治疗期间的不良反应。结果治疗前2组血浆黏度、红细胞刚性指数、红细胞聚集指数、全血黏度比较,差异无统计学意义(均P>0.05),治疗后2组以上指标水平均低于治疗前,且观察组低于对照组(均P<0.05)。治疗前2组黏附因子血浆内皮素(ET-1)及血清细胞间黏附因子1(ICAM-1)水平比较,差异无统计学意义(均P>0.05),治疗后2组ET-1及ICAM-1水平均低于治疗前,且观察组低于对照组(均P<0.05)。治疗前2组炎症因子IL-6、IL-8、TNF-α及hs-CRP比较,差异无统计学意义(均P>0.05),治疗后2组以上指标水平均低于治疗前,且观察组低于对照组(均P<0.05)。观察组有效率高于对照组(92.31%vs.76.91%,χ^(2)=4.727,P=0.030)。2组总不良反应发生率(11.45%vs.9.62%)比较,差异无统计学意义(χ^(2)=0.102,P=0.749)。结论前列地尔联合脉络宁注射液治疗下肢ASO,可改善患者血液流变学指标,调节黏附因子与炎症因子水平,且未增加不良反应,安全性较高,疗效显著。Objective To investigate the effect of Mailuoning injection on blood circulation and vascular endothelium in lower extremity arteriosclerosis obliterans(ASO).Methods A total of 104 lower extremity ASO patients treated in the Second Affiliated Hospital of Zhengzhou University from January 2018 to January 2020 were enrolled and were divided into control group(52 cases)and observation group(52 cases)according to the random number table method.The control group was treated with Alprostadil injection,and the observation group was treated with Alprostadil injection combined with Mailuoning.The blood rheology indexes,adhesion factors and inflammatory factor levels of the two groups were compared before and after treatment,and the short-term clinical efficacy and adverse reactions during the treatment of the two groups were compared.Results No significant difference in plasma viscosity,erythrocyte stiffness index,erythrocyte aggregation index and whole blood viscosity was found between the two groups before treatment(all P>0.05).After treatment,the levels of five indicators in the two groups were lower than before treatment,and the observation group was lower in the control group(all P<0.05).No significant differences in the levels of adhesion factor ET-1 and ICAM-1 in the two groups before treatment(all P>0.05).After treatment,the levels of ET-1 and ICAM-1 in the two groups were lower than those before treatment,and the levels in the observation group were lower than those of control group(all P<0.05).No significant difference in serum inflammatory factors IL-6,IL-8,TNF-αand hs-CRP was found between the two groups before treatment(all P>0.05).After treatment,the levels of four indicators in the two groups were lower than those before treatment,and the observation group had lower levels than the control group(all P<0.05).The effective rate of the observation group was higher than that of the control group(92.31%vs.76.91%,χ^(2)=4.727,P=0.030).No serious adverse reactions were observed in the two groups,and the total adv

关 键 词：下肢动脉硬化闭塞症 前列地尔 脉络宁 血液循环 黏附因子 

分 类 号：R543.5[医药卫生—心血管疾病]