2008—2020年南充市艾滋病患者抗病毒治疗效果分析  

Analysis of antiviral treatment effect of AIDS in Nanchong City from 2008 to 2020

作　　者：吴鹏[1] 张芹[1] 吴涛[1] 兰洪兵 车双双 WU Peng;ZHANG Qin;WU Tao;LAN Hong-bing;CHE Shuang-shuang(Nanchong City Center for Disease Control and Prevention,Nanchong 637000,Sichuan Province,China)

机构地区：[1]南充市疾病预防控制中心,四川南充637000

出　　处：《预防医学情报杂志》2022年第9期1199-1203,1208,共6页Journal of Preventive Medicine Information

摘　　要：目的 了解2008—2020年南充市艾滋病患者的抗病毒治疗效果及影响因素。方法 采用回顾性队列研究,收集2008—2020年南充市艾滋病抗病毒治疗患者基本信息和治疗信息,比较不同治疗时间患者CD4^(+) T淋巴细胞和病毒载量变化,采用Logistic回归评价免疫恢复、病毒抑制效果及影响因素,检验水准α=0.05。结果 纳入4 430例研究对象,截至观察终点,排除失访、死亡和转出患者,CD4^(+) T淋巴细胞恢复成功比例为35.11%,其中基线CD4^(+) T淋巴细胞0~199.99个/μl、200~349.99个/μl和350~499.99个/μl的患者CD4^(+) T淋巴细胞恢复成功的比例分别为17.71%、40.01%和58.99%;基线CD4^(+) T淋巴细胞计数越高,治疗后成功恢复的比例越高、所需时间越短;治疗6、12、24、36和48个月后,病毒抑制成功比例分别为82.02%、82.37%、83.77%、85.94%和87.27%;开始治疗时的年龄、婚姻状况、确证到开始治疗时间、CD_(4)恢复情况对病毒学效果有影响。结论 艾滋病抗病毒治疗对于患者降低病毒载量、恢复和重建免疫系统均有积极效果,坚持早发现、早治疗、规范治疗是抗病毒治疗成功的核心,应高度关注中老年群体、离异、丧偶或分居等重点人群的治疗依从性教育。Objective To understand the efficacy and influencing factors of antiviral therapy among AIDS patients in Nanchong city from 2008 to 2020.Methods A retrospective cohort study was conducted to collect basic information and treatment information of AIDS patients treated with antiviral therapy in Nanchong city from 2008 to 2020.The changes of CD4^(+)T lymphocytes and viral load in patients with different treatment periods were compared,and immune recovery,viral inhibition effect and influencing factors were evaluated by using Logistic regression.The test level wasα=0.05.Results A total of 4430 subjects were included in the study.By the end point of observation,the successful recovery rate of CD4^(+)T lymphocytes was 35.11%,excluding the patients who were lost to follow-up,died or transferred out.Among the patients with 0~199.99/μl,200~349.99/μl and 350~499.99/μl baseline CD4^(+)T lymphocytes,the proportion of successful recovery of CD4^(+)T lymphocytes was 17.71%,40.01%and 58.99%,respectively.The higher the baseline CD4^(+)T lymphocyte count,the higher the proportion of successful post-treatment recovery and the shorter the time required.After 6,12,24,36 and 48 months of treatment,the successful rates of viral load suppression were 82.02%,82.37%,83.77%,85.94%and 87.27%,respectively.Age at the beginning of treatment,marital status,time from confirmation to the beginning of treatment,and CD4 recovery had an impact on the virologic effect.Conclusions HIV antiviral therapy has positive effects on reducing viral load and restoring and reconstructing immune system.Adherence to early detection,early treatment and standardized treatment is the core of successful antiviral therapy,and high attention should be paid to the treatment compliance education of middleaged and elderly groups,divorced,widowed or separated key groups.

关 键 词：艾滋病 抗病毒治疗 治疗效果 

分 类 号：R512.91[医药卫生—内科学]