一种新的极度胰岛素抵抗——C型胰岛素抵抗综合征的临床特点  

A new type of extreme insulin resistance—type C insulin resistance syndrome and its clinical characteristics

作　　者：梁思宇 陈适[1] 黎明[1] 袁涛[1] 孙立泽 刘赫[1] 王鸥[1] 李玉秀[1] Liang Siyu;Chen Shi;Li Ming;Yuan Tao;Sun Lize;Liu He;Wang Ou;Li Yuxiu(Department of Endocrinology,Endocrine Key Laboratory of National Health Commission of the People′s Republic of China,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院内分泌科,卫生部内分泌重点实验室100730 [2]中国医学科学院,北京协和医学院,北京协和医院100730

出　　处：《中华内分泌代谢杂志》2022年第8期674-678,共5页Chinese Journal of Endocrinology and Metabolism

摘　　要：报告北京协和医院内分泌科2000年1月至2020年12月收治的2例C型胰岛素抵抗综合征(type C insulin resistance syndrome,TCIRS),患者以持续性高血糖、低免疫反应性胰岛素、极度胰岛素抵抗、高胰岛素自身抗体、高总胰岛素为特征,临床常表现为极度胰岛素抵抗伴酮症酸中毒,中至大剂量糖皮质激素治疗有效,血浆置换效果不佳。We report on two cases of type C insulin resistance syndrome(TCIRS)admitted to the Department of Endocrinology,Peking Union Medical College Hospital from January 2000 to December 2020.Both patients presented with persistent hyperglycemia,low immunoreactive insulin,extreme insulin resistance,high insulin autoantibodies,high total insulin,and large insulin antibody pool.TCIRS is marked by extreme insulin resistance with ketoacidosis and respond to medium to high doses glucocorticoids rather than plasmapheresis.

关 键 词：高血糖 胰岛素抵抗 胰岛素自身免疫综合征 胰岛素抗体 

分 类 号：R589[医药卫生—内分泌]