PET自动给药系统降低核医学护理辐射剂量和提高注射精度的研究  

Study of PET automatic drug infusion system for radiation protection and precision injection in nuclear medicine nursing

作　　者：戚勤励 赵凌舟[1] 郭李磊 陈栋晖 张英[1] 赵晋华[1] Qi Qinli;Zhao Lingzhou;Guo Lilei;Chen Donghui;Zhang Ying;Zhao Jinhua(Department of Nuclear Medicine,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China;Comprehensive Cancer Center,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China)

机构地区：[1]上海交通大学医学院附属第一人民医院核医学科,上海200080 [2]上海交通大学医学院附属第一人民医院肿瘤中心,上海200080

出　　处：《中华核医学与分子影像杂志》2022年第9期547-549,共3页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家自然科学基金(81971647)。

摘　　要：目的比较人工给药与自动给药的辐射剂量和注射精度,评价PET自动给药系统在护理工作中的优势。方法人工给药和PET自动给药系统各完成2021年8月至2021年9月间上海交通大学医学院附属第一人民医院20例患者(共40例,其中男27例,女13例,平均年龄59.6岁)的^(18)F-FDG注射;手持式辐射探测器测量2种给药方式护士的手臂和躯干剂量当量率,记录给药时长,比较2种注射方式的年辐射剂量。采用两独立样本t检验比较2种给药方式注射参数的差异。结果按每年5000例患者估算,人工给药时护士手臂和躯干的年辐射剂量为220.19和2.09 mSv,自动给药为0.19和0.08 mSv,分别减少了99%和95%。人工给药和自动给药的空针活度分别为(18.87±7.77)和(0.22±0.19)MBq,差异有统计学意义(t=10.65,P<0.001),而满针活度、注射活度以及注射活度与处方活度的比值差异均无统计学意义(t值:-0.03~1.37,均P>0.05)。结论PET自动给药系统为核医学护理带来更好的防护。Objective To evaluate the advantages of PET automatic drug infusion system in nuclear medicine nursing by comparing radiation dose and precision injection between artificial injection and automatic injection.Methods From August 2021 to September 2021,40 patients(27 males,13 females,average age:59.6 years)were divided into two groups(20 patients in each group)for the injection of ^(18)F-FDG by artificial injection and automatic injection in Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine.Portable radiation detector was used to measure the peak values of dose-equivalent rate in the arm and trunk of the nurse during the administration.The duration of administration process was recorded and the annual radiation doses were estimated and compared between the two injection methods.Independent-sample t test was used to compare the differences of injection parameters between two methods.Results Based on 5000 patients injected annually by artificial injection,the estimated annual radiation doses were about 220.19 mSv in the arm and 2.09 mSv in the trunk,while the radiation doses were approximately 0.19 and 0.08 mSv by automatic administration,respectively.Compared with the artificial injection,the automatic drug infusion system could reduce by 99%and 95%of equivalent doses in the arm and trunk,respectively.The significant difference was found in the empty needle activity between artificial injection and automatic drug infusion system((18.87±7.77)and(0.22±0.19)MBq;t=10.65,P<0.001),while there were no statistical differences in full needle activity,injection activity and injection/prescription activity ratio(t values:from-0.03 to 1.37,all P>0.05).Conclusion PET automatic drug infusion system provides better radiation protection for nuclear medicine nursing.

关 键 词：给药系统 护理 辐射防护 辐射剂量 正电子发射断层显像术 氟脱氧葡萄糖F18 

分 类 号：R473[医药卫生—护理学]