重组结核杆菌融合蛋白在学生结核病筛查中的应用  

Study on the application of recombinant mycobacterium tuberculosis fusion protein in tuberculosis screening of students

作　　者：牟廷梅 胡启源 李文 冯燕娥 王显贵[2] MU Ting-mei;HU Qi-yuan;LI Wen;FENG Yan-e;WANG Xian-gui(Mingshan District Center for Disease Control and Prevention,Yaan 625100,Sichuan Province,China;Yaan Center for Disease Control and Prevention,Yaan 625000,Sichuan Province,China)

机构地区：[1]雅安市名山区疾病预防控制中心,四川雅安625100 [2]雅安市疾病预防控制中心,四川雅安625000

出　　处：《寄生虫病与感染性疾病》2022年第3期166-170,共5页Parasitoses and Infectious Diseases

摘　　要：目的 探索重组结核杆菌融合蛋白(EC)在中小学生结核病筛查中的适宜性,获得雅安市名山区中小学生的结核潜伏感染基数,为结核病低疫情地区的学校结核病筛查提供数据支持。方法 于2021-05/09对雅安市名山区25 906名中小学生以重组结核杆菌融合蛋白(EC)方法进行结核病潜伏感染筛查,采用Excel 2013和SPSS 20.0软件进行数据的录入和统计学分析,计数资料用百分率描述。年龄组间阳性率采用χ_(趋势)^(2)检验,不同性别和学校类型间的阳性率比较采用χ^(2)检验,以P<0.05为差异有统计学意义。结果 名山区中小学生的整体结核潜伏感染率为0.89%;年级越高,结核潜伏感染率越高;年龄越大,结核潜伏感染率也越高;女学生潜伏感染率高于男学生;高疫情地区来的学生结核潜伏感染率高于本地学生。结论 重组结核杆菌融合蛋白(EC)可用于结核病低疫情地区的大规模学生结核潜伏感染调查。Objective To explore the suitability of recombinant mycobacterium tuberculosis fusion protein(EC) in tuberculosis screening for primary and secondary school students,to obtain the TB latent infection base of primary and secondary school in Mingshan District of Yaan City,and to provide data to support tuberculosis screening in schools with low TB epidemics areas.Methods From May to September in 2021,EC skin testing was conducted for tuberculosis latent infection screening on 25 906 primary and secondary school students in Mingshan District.Excel 2013 and SPSS 20.0software were used for data entry and statistical analysis.Enumeration data were described by“percentage (%) ”.The χ_(trend)^(2) was used for the positive rate between age groups,and the χ^(2) test was used to compare the positive rate between different genders and different school types,and P<0.05 was considered statistically significant.Results The overall latent TB infection rate of primary and secondary school students in Mingshan District was 0.89%.The higher the grade,the higher the TB latent infection rate;The older the age,the higher the TB latent infection rate;The latent infection rate of female students was higher than that of male students;Students from the high epidemic areas have higher TB infection latent rate than that of local students.Conclusions Recombinant mycobacterium tuberculosis fusion protein(EC) can be used for large-scale investigation of latent tuberculosis infection among students in low-prevalence areas of tuberculosis.

关 键 词：重组结核杆菌融合蛋白(EC) 学校结核 结核病潜伏感染 

分 类 号：R52[医药卫生—内科学]