基于中医传承辅助平台分析含丹参-川芎药对方剂的组方规律  

Analysis of Prescription Rules For the Prescriptions Containing Salvia miltiorrhiza and Ligusticum chuanxiong Drug Pair Based on TCM Inheritance Support Platform

作　　者：张聪 张雷[2] ZHANG Cong;ZHANG Lei(Rehabilitation Hospital of Kunshan,Kunshan 215300,China;Traditional Chinese Medicine Hospital of Kunshan,Kunshan 215300,China)

机构地区：[1]昆山市康复医院,江苏昆山215300 [2]昆山市中医医院,江苏昆山215300

出　　处：《中国民族民间医药》2022年第19期96-100,共5页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:分析含丹参-川芎药对的中成药组方规律,为拓展临床应用提供依据。方法:收集《新编国家中成药》(第2版)和药智数据中包含丹参-川芎的方剂,录入中医传承辅助平台软件(V3.0)建立数据库,对主治病症、配伍药材、组方归经等频次进行统计,挖掘得到含丹参-川芎方剂的核心药材组合(支持度分别为25、 35、 45,置信度为0.90);选择频次较高的代表性主治疾病冠心病和月经不调进行组方规律分析。通过kmeans算法和回归模拟分析,演化出最佳核心方药组合。结果:共筛选出155首含丹参-川芎药对的方剂,涉及主治疾病8种(频次≥4),包括冠心病、中风、月经不调等;涉及主治证候10种(频次≥5),包括气滞血瘀证、气血两虚证、寒凝血瘀证等;组方主要归肝、心、脾经。常配伍药材17味(频次≥15),包括当归、红花、黄芪及赤芍等;常用药材组合10个(支持度为35,频次> 50),包括川芎-当归、丹参-红花、丹参-川芎-黄芪等。常与丹参-川芎配伍治疗冠心病的核心药材为赤芍、红花和葛根,治疗月经失调的核心药材为当归、香附、白芍、白术;聚类分析后得到8组核心方药。结论:《新编国家中成药》(第2版)和药智数据中含丹参-川芎方剂主治疾病以风、寒、痰、瘀为主,组方药物多为养血活血、清热健脾之品。此外,对核心方药的组方分析,反映了经方裁化应用于临床的现代组方特点。Objective To analyze the prescription rule of Chinese Patent Drugs containingSalvia miltiorrhizaand Ligusticum chuanxiong drug pair (“cinnamon-dried ginger” for short), so as to provide a basis for expanding clinical application.MethodsThe prescriptions containingSalvia miltiorrhizaandLigusticum chuanxiongwere collected from “the newly compiled National proprietary Chinese Medicine(2nd edition) ” and drug wisdom data and input into TCM inheritance support platform software(V3. 0) to establish a database. The frequency of attending diseases, compatibility medicinal materials, and meridian of drug were analyzed statistically.And the core combination of medicinal materials in the prescriptions containingSalvia miltiorrhizaandLigusticum chuanxiongwere excavated(support degrees were 25, 35, 45, confidence was 0. 90). The coronary heart disease and irregular menstruation with the high frequency of attending diseases were selected to analyze in respect of prescription rules. Through kmeans algorithm and regression simulation analysis, the best core prescription combination is evolved.ResultsA total of 155 prescriptions containingSalvia miltiorrhizaandLigusticum chuanxiongwere screened, eight kinds of attending diseases(frequency ≥4), such as coronary heart disease,stroke, irregular menstruation, etc. Ten kinds of attending syndrome(frequency ≥5) were included such as qi stagnation and blood stasis syndrome, qi and blood deficiency syndrome, cold coagulation and blood stasis syndrome, etc. Meridian of drug with higher compatibility frequency was distributed to liver, heart and spleen. There were 17 commonly used compatibility medicinal materials(frequency≥15), includingAngelicae Sinensis Radix,Carthami Flos,Radix AstragaliandRadix Paeoniae Rubraetc. There were 10commonly used medicinal materials combinations(support degrees were 35, frequency > 50), includingLigusticum chuanxiong-Angelica sinensis,Salvia miltiorrhiza-Carthami FlosandSalvia miltiorrhiza-Ligusticum chuanxiong-Astragalus membranaceusand so on.

关 键 词：中医传承辅助平台 丹参 川芎 冠心病 月经不调 组方规律 

分 类 号：R289[医药卫生—方剂学]