中药治疗慢性疲劳综合征的Meta分析  

Meta-analysis of TCM Treatment For Chronic Fatigue Syndrome

作　　者：杨春[1,2] 云洁 杨梅[3] 袁佳丽[2] 蔡君洁 YANG Chun;YUN Jie;YANG Mei;YUAN Jiali;CAI Junjie(Sichuan College of Traditional Chinese Medicine,Mianyang 621000,China;Chengdu University of Traditional Chinese Medicine,Chengdu 610000,China;Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610000,China)

机构地区：[1]四川中医药高等专科学校,四川绵阳621000 [2]成都中医药大学,四川成都610000 [3]成都中医药大学附属医院,四川成都61000

出　　处：《中国民族民间医药》2022年第19期104-110,共7页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：四川省干部保健科研课题(编号:川干研2020-503)。

摘　　要：目的:系统评价中药治疗慢性疲劳综合征的临床有效性及安全性。方法:主要采用主题词和自由词相结合的方式,检索中医药治疗CFS的RCT文献,检索数据库包括中国知网(CNKI)、万方(WF)、维普(VIP)、中国生物医学文献数据库(CBM)、 PubMed、 Web of Science、 The Cochrane Library、 Embase,检索时间从建库至2021年7月。根据纳排标准筛选文献,按Cochrane系统评价标准(5.1.0)对纳入文献进行质量评估,运用Revman 5.4软件进行统计分析。结果:纳入35篇文献共2878例患者,结果显示,中药组治疗CFS的总有效率高于非中医治疗组(P<0.00001, RR=1.47, 95%CI [1.40, 1.55]);中药组疲劳量表FS-14得分低于非中医组(P<0.00001, MD=-1.72, 95%CI [-1.81,-1.62]);中药组免疫指标改善高于非中医组,差异有统计学意义;纳入研究中6项报告了安全性,患者无严重不良反应。结论:中药可提高CFS的临床疗效,改善疲劳与免疫功能,用药安全。Objective To systematically evaluate the clinical efficacy and safety of Traditional Chinese medicine in the treatment of chronic fatigue syndrome.Methods The RCT literature on TCM treatment of CFS was searched by the combination of subject words and free words. The databases included CNKI, WF, VIP, CBM, PubMed, Web of Science, The Cochrane Library and Embase, and The retrieval period was from The establishment of The database to July 2021. The literature was screened according to the grading criteria, and the quality of the included literature was assessed according to the Cochrane systematic evaluation standard(5. 1. 0). Statistical analysis was conducted by using Revman 5. 4 software.Results A total of 2878 patients were included in 35 literatures. The results showed that the total effective rate of CFS in TCM group was higher than that in non-TCM group [P< 0. 00001, RR = 1. 47,95% CI(1. 40, 1. 55)]. The fS-14 score in the TCM group was lower than that in the non-TCM group [P<0. 00001, MD =-1. 72,95% CI(-1. 81,-1. 62)]. The improvement of immune indexes in TCM group was higher than that in non-TCM group, and the difference was statistically significant. Safety was reported in six of the included studies, with no serious adverse events in patients.Conclusion Traditional Chinese medicine can improve the clinical efficacy of CFS, fatigue and immune function, and drug safety.

关 键 词：慢性疲劳综合征 中药 META分析 

分 类 号：R255.5[医药卫生—中医内科学]