经会阴超声测量宫颈长度联合胎儿纤维连接蛋白及血清松弛素在胎儿早产预防中的意义  

Significance of transperineal ultrasound cervical length measurement combined with fetal fibronectin and serum relaxin quantification in prevention of fetal preterm delivery

作　　者：王晨雨[1] 喻红霞[1] 王颍超 Wang Chenyu;Yu Hongxia;Wang Yingchao(Department of Ultrasonography,Second Affiliated Hospital of Zhengzhou University,Henan 450000,China;Department of Interventional Medicine,Zhengzhou People's Hospital,Henan 450000,China)

机构地区：[1]郑州大学第二附属医院超声科,450000 [2]河南省郑州人民医院介入科,450000

出　　处：《实用医技杂志》2022年第8期806-809,共4页Journal of Practical Medical Techniques

摘　　要：目的探讨经会阴超声测量宫颈长度(CL)联合血清松弛素及胎儿纤维连接蛋白(fFN)在预防胎儿早产中的意义。方法选取2018年12月至2020年3月郑州大学第二附属医院收治的先兆早产孕妇90例,按照妊娠结局分为早产组(42例)和足月组(48例)。经会阴超声测量孕妇的CL,酶联免疫吸附试验(ELISA)检测血清松弛素宫颈分泌物f FN水平,比较早产组和足月组间CL、松弛素及fFN水平差异,评估CL、松弛素及fFN单独及其联合时诊断早产的特异度和敏感度。结果早产组孕妇的CL[(26±7)mm]低于足月组[(31±11)mm],fFN[(75±17)ng/ml]及松弛素水平[(315±65)ng/ml]均高于足月组[分别为(49±15)ng/ml,(272±56)ng/ml,均P<0.05]。CL、fFN、松弛素单独预测早产的敏感度分别为71.43%、88.10%和76.19%,特异度分别为85.42%、62.50%和83.33%;三者的联合指标预测早产的敏感度和特异度分别为97.62%和91.67%,显著高于单一指标。结论血清松弛素对于早产有一定预测价值,CL、fFN联合松弛素对早产的诊断性能优于单一指标。Objective To investigate the significance of transperineal ultrasound measurement of cervical length(CL)combined with serum relaxin and fetal fibronectin(fFN)quantification in preventing fetal preterm delivery.Methods A total of 90 pregnant women with threatened preterm delivery admitted to Second Affiliated Hospital of Zhengzhou University between December 2018 and March 2020 were included and divided into the preterm delivery group(n=42)and the term delivery group(n=48)according to pregnancy outcome.The CL of pregnant women was measured by transperineal ultrasonography.The relaxin level in serum and fFN in cervical secretion were quantified by enzyme-linked immunosorbent assay(ELISA).The preterm delivery group and the term delivery group were compared for CL and levels of relaxin and fFN.The specificity and sensitivity of CL,relaxin and fFN used alone or in combination in diagnosing preterm delivery were evaluated.Results Compared with the term delivery group,the preterm delivery group had significantly shorter CL[(26±7)mm vs(31±11)mm],significantly higher fFN[(75±17)ng/ml vs(49±15)ng/ml]and relaxin[(315±65)ng/ml vs(272±56)ng/ml](all P<0.05).The sensitivity of CL,fFN and relaxin used alone in predicting preterm delivery was 71.43%,88.10% and 76.19%,respectively,and the specificity was 85.42%,62.50% and 83.33%,respectively.The sensitivity and specificity of the three indicators used in combination for predicting preterm delivery were 97.62% and 91.67%,respectively.These values were significantly higher than those with any of the three indicators used alone.Conclusion Serum relaxin has a role in prediction of preterm delivery.The diagnostic performance with CL,fFN and relaxin in combination outmatches any of these indicators used alone.

关 键 词：早产 宫颈长度测量 松弛素 胎儿纤维连接蛋白 

分 类 号：R714.21[医药卫生—妇产科学]