血清sCD163/sTWEAK比值对AMI患者PCI术后冠脉支架内再狭窄的预测价值  

Predictive value of serum sCD163/sTWEAK ratio for coronary in-stent restenosis after PCI in AMI patients

作　　者：郑欣 靳梦 何涛 石家冲 ZHENG Xin;JIN Meng;HE Tao;SHI Jia-chong(Department of Laboratory,Hubei Jianghan Oilfield General Hospital,Qianjiang,Hubei,433100,China)

机构地区：[1]湖北江汉油田总医院检验科,湖北潜江433100 [2]长江大学附属潜江市中心医院心血管内科

出　　处：《心血管康复医学杂志》2022年第5期581-585,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:研究血清可溶性血红蛋白清道夫受体(sCD163)/可溶性肿瘤坏死因子样凋亡弱诱导因子(sTWEAK)比值对急性心肌梗死(AMI)患者行经皮冠状动脉介入治疗(PCI)术后发生冠脉支架内再狭窄(ISR)的预测价值。方法:依据是否发生ISR,于我院行PCI术的180例AMI患者被分为非ISR组(128例)和ISR组(52例)。比较两组一般临床资料、血清sCD163、sTWEAK水平、sCD163/sTWEAK比值。分析AMI患者PCI术后发生ISR的影响因素及sCD163/sTWEAK比值对ISR发生的预测价值。结果:与非ISR组比较,ISR组血清总胆固醇、低密度脂蛋白胆固醇、sCD163及sTWEAK水平、sCD163/sTWEAK比值显著升高(P均=0.001)。多因素Logistic回归分析显示,sCD163/sTWEAK比值是AMI患者PCI术后发生ISR的独立危险因素(OR=1.351,P=0.018)。ROC曲线分析显示,sCD163/sTWEAK比值预测AMI患者PCI术后发生ISR的曲线下面积为0.754,截断值为1.14,灵敏度为86.50%,特异度为60.90%。结论:血清sCD163/sTWEAK比值是急性心肌梗死患者PCI术后发生ISR的独立危险因素,且对ISR发生具有一定预测价值。Objective:To study predictive value of serum soluble cluster differentiation 163(sCD163)/soluble tumor necrosis factor-like weak inducer of apoptosis(sTWEAK)ratio for coronary in-stent restenosis(ISR)in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods:According to whether ISR occurred,a total of 180 AMI patients undergoing PCI in our hospital were divided no ISR group(n=128)and ISR group(n=52).General clinical data,serum levels of sCD163,sTWEAK and sCD163/sTWEAK ratio were compared between two groups.Influencing factors of ISR after PCI in AMI patients and predictive value of sCD163/sTWEAK ratio for occurrence of ISR were analyzed.Results:Compared with no ISR group,there were significant rise in serum levels of total cholesterol,low-density lipoprotein cholesterol,sCD163,sTWEAK and sCD163/sTWEAK ratio in ISR group(P=0.001 all).Multivariate Logistic regression analysis indicated that sCD163/sTWEAK ratio was an independent risk factor for ISR after PCI in AMI patients(OR=1.351,P=0.018).ROC curve analysis indicated that AUC of sCD163/sTWEAK ratio for predicting ISR after PCI in AMI patients was 0.754,cutoff point was 1.140,sensitivity was 86.50%and specificity were 60.90%.Conclusion:Serum sCD163/sTWEAK ratio is an independent risk factor for ISR in patients with acute myocardial infarction after PCI,and it possesses certain predictive value for occurrence of ISR.

关 键 词：心肌梗死 血管成形术 气囊 冠状动脉 支架 

分 类 号：R542.22[医药卫生—心血管疾病]