肌肉生长抑制素在糖尿病相关心肾疾病中的作用  

Role of myostatin in diabetes mellitus-related cardiorenal diseases

作　　者：李翠 LI Cui(Department of Endocrinology and Metabolism,Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,150086,China)

机构地区：[1]哈尔滨医科大学附属第二医院内分泌与代谢病科,黑龙江哈尔滨150081

出　　处：《心血管康复医学杂志》2022年第5期657-660,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：肌肉生长抑制素(MSTN)是骨骼肌生长发育的负调控因子,缺乏MSTN的小鼠由于肌肉纤维肥大和增生导致骨骼肌质量增加。最近的研究表明MSTN的表达还与胰岛素抵抗的发生密切相关,同时也参与糖尿病相关心肾并发症的发生与发展。本文就MSTN在糖尿病相关心肾疾病中的作用作一综述。Myostatin(MSTN)is a negative regulator of skeletal muscle growth and development,and muscle fiber hypertrophy and hyperplasia lead to increased skeletal muscle mass addition in mice lacking MSTN.Recent studies have indicated also that expression of MSTN is not only closely related to occurrence of insulin resistance,but also involved in occurrence and development of diabetes mellitus-related cardio-renal complications.The present article makes a review on role of MSTN in diabetes-related cardiorenal disease.

关 键 词：糖尿病肾病 肌肉生长抑制素 纤维化 

分 类 号：R587.24[医药卫生—内分泌]