宫颈酸性磷酸酶对宫颈异常细胞进行分流的临床意义  

Clinical Significance of Cervical Acid Phosphatase in Shunt of Abnormal Cervical Cells

作　　者：孔庆杨[1] 董晓斌[2] 王英 班宏艳 郎晓多 KONG Qingyang;DONG Xiaobin;WANG Ying(Department of Pathology,Jilin Provincial Maternal and Child Health Hospital(Jilin Provincial Obstetrics Quality Control Center),Changchun City,Jilin Province 130051;不详)

机构地区：[1]吉林省妇幼保健院(吉林省产科质量控制中心)病理科,吉林省长春市130051 [2]吉林省妇幼保健院(吉林省产科质量控制中心)院长办公室,吉林省长春市130051 [3]吉林省双辽市妇幼保健计划[JZ]生育服务中心细胞室 [4]吉林大学第一医院病理中心 [5]吉林省妇幼保健院(吉林省产科质量控制中心)体检中心

出　　处：《医学理论与实践》2022年第20期3436-3438,共3页The Journal of Medical Theory and Practice

摘　　要：目的:探讨以宫颈酸性磷酸酶(CAP)为标志物,对宫颈细胞学检查结果为未明确意义的非典型鳞状上皮细胞(ASC-US)进行辅助诊断的意义。方法:对近5年在送检本院经液基细胞学检查(TCT)被诊断为ASC-US的患者采用酸性磷酸酶免疫细胞化学染色,对结果进行统计分析。以组织学结果为金标准,判断酸性磷酸酶为标志物的诊断价值。结果:经免疫细胞化学染色后,CAP在鳞状上皮内病变患者组织细胞中阳性表达,而在炎症患者组织细胞中较少表达。结论:CAP染色能够辅助宫颈细胞学检查结果为ASC-US进行明确诊断,进一步判别是否发生病变。Objective:To investigate the diagnostic significance of cervical acid phosphatase(CAP) as a marker for atypical squamous epithelial cells(ASC-US) whose cervical cytology results were not clear.Methods:Acid phosphatase immunocytochemical staining was performed on ASC-US patients who were diagnosed by liquid based cytology(TCT) in our hospital in recent 5 years, and the results were statistically analyzed.The diagnostic value of acid phosphatase as a marker was evaluated with histological results as the gold standard.Results:After immunocytochemical staining, acid phosphatase was positively expressed in cells of patients with squamous intraepithelial disease, but CAP was less expressed in cells of patients with inflammation.Conclusion:Acid phosphatase staining can assist in the diagnosis of ASC-US with undefined significance in cervical cytology, and further distinguish the occurrence of lesions.

关 键 词：未明确意义的非典型鳞状上皮细胞 酸性磷酸酶 宫颈异常细胞 免疫细胞化学染色 

分 类 号：R446[医药卫生—诊断学]