去甲基化酶LSD1调控自噬的研究进展  

Research progress of autophagy regulated by demethylase LSD1

作　　者：时迎旭 周永 宋富强[1] 王海滨[1] 高明[1] SHI Yingxu;ZHOU Yong;SONG Fuqiang;WANG Haibin;GAO Ming(Department of Orthopedic Trauma,Affiliated Hospital of Jining Medical University,Jining 272007,China;Second Ward of Orthopedics,Suining Central Hospital,Suining 629000,China)

机构地区：[1]济宁医学院附属医院创伤骨科,济宁272007 [2]四川省遂宁市中心医院骨科中心二病区,遂宁629000

出　　处：《生命的化学》2022年第8期1453-1460,共8页Chemistry of Life

基　　金：山东省中医药科技项目(2021Q085);济宁市重点研发计划项目(2021YXNS067);济宁医学院高层次科研项目培育项目(JYGC2021FKJ007)。

摘　　要：自噬是受到精密调控的细胞自我更新过程,表观遗传调控是自噬的重要调控机制。作为常见的表观遗传调控酶,赖氨酸特异性去甲基化酶1(lysine-specific demethylase 1,LSD1)是生物治疗的靶点与研究热点。LSD1在转录水平与翻译后修饰水平对自噬相关分子的调控,在炎症转归、肿瘤进展、细胞存亡等生物学过程中发挥着重要作用。因此,综述LSD1调控自噬的机制对于探索疾病治疗的新靶点并丰富疾病的治疗方案具有重要参考意义。Autophagy is an orchestrated cellular self-renewal progress,in which epigenetic regulation plays an important role.As a common demethylase,lysine-specific demethylase 1(LSD1)is the target and hotspot of biological therapy.LSD1 regulates autophagy-related molecules at transcriptional level and post translational modification level,which is closely related to biological processes including inflammation,carcinogenesis,and cell fate.Therefore,reviewing the molecular mechanisms of LSD1 regulates autophagy is critical for exploring the novel target and enriching therapy design of disease.

关 键 词：赖氨酸特异性去甲基化酶1抑制剂 表观遗传调控 哺乳动物雷帕霉素靶蛋白 非组蛋白底物 去甲基化非依赖途径 

分 类 号：R346[医药卫生—基础医学]