CircRNA在心血管疾病诊治中的作用  

Diagnostic and therapeutic role of circRNA in cardiovascular diseases

作　　者：钱海燕 张泽波 殷玥琪 陶臻博 张莉娜 QIAN Haiyan;ZHANG Zebo;YIN Yueqi;TAO Zhenbo;ZHANG Li’na(Zhejiang Provincial Key Laboratory of Pathophysiology,School of Medicine,Ningbo University,Ningbo 315211,China)

机构地区：[1]宁波大学医学院浙江省病理生理学技术研究重点实验室,宁波315211

出　　处：《生命的化学》2022年第8期1470-1477,共8页Chemistry of Life

基　　金：浙江省公益技术应用研究资助项目(LGF21H260006);宁波大学研究生科研创新基金项目(IF2022188,IF2022192)。

摘　　要：环状RNA(circular RNA,circRNA)是一种新型的内源性RNA分子,具有共价结合的环状结构,广泛存在于真核细胞中,并通过多种方式参与基因的表达和调控,已成为非编码RNA领域的研究热点。CircRNA与心血管疾病的生理和病理过程密切相关,且具有诊断及治疗心血管疾病的潜力。本文重点综述了circRNA在几种心血管疾病中作为诊断标志物和治疗靶点的作用,并对其应用价值和发展前景进行展望。Circular RNA(circRNA)is a novel class of endogenous RNA molecule with a covalently closedloop structure and has become a research hotspot in the field of non-coding RNA.It is widely present in eukaryotic cells and can be involved in gene expression and regulation in various ways.In recent years,many studies have shown that circRNA is closely related to the physiological and pathological processes of cardiovascular diseases,and has the potential to diagnose and treat cardiovascular diseases.This review focuses on the role of circRNA as a diagnostic biomarker and therapeutic target for cardiovascular diseases,and looks into its application value and development direction.

关 键 词：环状RNA 心血管疾病 诊断标志物 潜在治疗靶点 

分 类 号：R54[医药卫生—心血管疾病]