H型高血压患者血浆同型半胱氨酸水平与颈动脉粥样硬化的相关性分析  

The correlation analysis between plasma homocysteine level and carotid atherosclerosis in patients with essential hypertension

作　　者：熊玲兵 肖善花 黄剑锋[3] 钟伟兵 段勇 张必龙 赵宇[6] 江小杰 邱宇安 霍勇[9] 黄绍烈[10] 文丽生[11] 张爱华[11] Xiong Lingbing;Xiao Shanhua;Huang Jianfeng;Zhong Weibing;Duan Yong;Zhang Bilong;Zhao Yu;Jiang Xiaojie;Qiu Yu􀆳an;Huo Yong;Huang Shaolie;Wen Lisheng;Zhang Aihua(Second Department of Cardiovascular Medicine,the Third Hospital of Nanchang,Nanchang 330009,Jiangxi,China;Department of Nephrology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi,China;Department of Ultrasonic Diagnosis,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi,China;Department of Cardiovascular Medicine,the Third Hospital of Changsha,Changsha 410000,Hunan,China;Department of Cardiovascular Medicine,Ganzhou Municipal Hospital,Ganzhou 341000,Jiangxi,China;Department of Cardiovascular Medicine,the Fourth Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi,China;Department of Cardiovascular Medicine,the Third Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi,China;Department of Intensive Care Unit,Jiangxi Second People􀆳s Hospital,Nanchang 330006,Jiangxi,China;Department of Cardiovascular Medicine,Beijing University First Hospital,Beijing 100034,China;Department of Cardiovascular Medicine,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi,China;Physical Examination Center,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi,China)

机构地区：[1]南昌市第三医院心血管二科,江西南昌330009 [2]南昌大学第一附属医院肾内科,江西南昌330006 [3]南昌大学第一附属医院超声诊断科,江西南昌330006 [4]长沙市第三医院心血管内科,湖南长沙410000 [5]赣州市立医院心血管内科,江西赣州341000 [6]南昌大学第四附属医院心血管内科,江西南昌330006 [7]南昌大学第三附属医院心血管内科,江西南昌330006 [8]江西省第二人民医院重症监护病房,江西南昌330006 [9]北京大学第一医院心血管内科,北京100034 [10]南昌大学第一附属医院心血管内科,江西南昌330006 [11]南昌大学第一附属医院体检中心,江西南昌330006

出　　处：《中国医学前沿杂志（电子版）》2022年第10期26-30,共5页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：江西省科技厅重点项目(20171BBG70089)。

摘　　要：目的 研究H型高血压患者血浆同型半胱氨酸(homocysteine,Hcy)水平与颈动脉粥样硬化(carotid atherosclerosis,CAS)之间的关系。方法 将1 369例H型高血压患者(H型高血压组)与1 038例正常对照组进行比较,然后将H型高血压组患者,根据颈动脉彩色多普勒超声结果分为H型高血压1组及H型高血压2组,比较两组的Hcy、年龄、性别、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、肌酐(creatinine,Cr)、尿酸(uric acid,UA)、空腹血糖(fasting blood glucose,FBS)、吸烟及饮酒史等。结果H型高血压组与正常对照组CAS、Hcy、LDL-C、Cr、FBS 5个项目的比较,H型高血压组高于正常对照组,差异有统计学意义;H型高血压1组Hcy、年龄、Cr、FBS显著大于H型高血压2组,差异有统计学意义。结论 高同型半胱氨酸血症(hyperhomocysteinemia,HHcy)可能引起动脉粥样硬化(atherosclerosis,AS),在H型高血压患者中更高水平的Hcy可加重AS的程度。Objective To investigate the relationship between plasma homocysteine(Hcy)level and carotid atherosclerosis(CAS)in patients with H-type hypertension.Method 1 369 patients with H-type hypertension(H-type hypertension group)were compared with 1 038 normal controls,and then the H-type hypertension group was divided into H-type hypertension group 1 and H-type hypertension group 2 according to the results of carotid ultrasound.Hcy,age,sex,total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),creatinine(Cr),uric acid(UA),fasting blood glucose(FBS),history of hypertension,smoking and drinking history were compared between the two groups.Result The levels of CAS,Hcy,LDL-C,Cr and FBS in H-type hypertension group were higher than those in normal control group.Meanwhile,the level of Hcy,age,Cr,and FBS in h-type hypertension group 1 were significantly higher than those in H-type hypertension group 2.Both results are statistically significant.Conclusion Higher level of Hcy could aggravate the degree of AS in patients with H-type hypertension.

关 键 词：同型半胱氨酸 H型高血压 颈动脉粥样硬化 心脑血管疾病 

分 类 号：R544.1[医药卫生—心血管疾病] R543.4[医药卫生—内科学]